Tadatoshi Sato
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Explore the profile of Tadatoshi Sato including associated specialties, affiliations and a list of published articles.
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45
Citations
790
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Recent Articles
11.
Sato T, Verma S, Khatri A, Dean T, Goransson O, Gardella T, et al.
JBMR Plus
. 2021 May;
5(5):e10441.
PMID: 33977197
Multiple analogs of parathyroid hormone, all of which bind to the PTH/PTHrP receptor PTH1R, are used for patients with osteoporosis and hypoparathyroidism. Although ligands such as abaloparatide, teriparatide (hPTH 1-34...
12.
Sato T, Verma S, Castro Andrade C, Omeara M, Campbell N, Wang J, et al.
Nat Commun
. 2020 Jul;
11(1):3282.
PMID: 32612176
Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress (FFSS) across their dendritic projections. Loading-induced reductions...
13.
Fan Y, Liu W, Bi R, Densmore M, Sato T, Mannstadt M, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(16):E3749-E3758.
PMID: 29618612
The pathogenesis of parathyroid gland hyperplasia is poorly understood, and a better understanding is essential if there is to be improvement over the current strategies for prevention and treatment of...
14.
Komaba H, Kaludjerovic J, Hu D, Nagano K, Amano K, Ide N, et al.
Kidney Int
. 2017 Apr;
92(3):599-611.
PMID: 28396120
Osteocytes within the mineralized bone matrix control bone remodeling by regulating osteoblast and osteoclast activity. Osteocytes express the aging suppressor Klotho, but the functional role of this protein in skeletal...
15.
Sato T, Courbebaisse M, Ide N, Fan Y, Hanai J, Kaludjerovic J, et al.
Proc Natl Acad Sci U S A
. 2017 Apr;
114(16):E3344-E3353.
PMID: 28373577
Renal Ca reabsorption is essential for maintaining systemic Ca homeostasis and is tightly regulated through the parathyroid hormone (PTH)/PTHrP receptor (PTH1R) signaling pathway. We investigated the role of PTH1R in...
16.
Kaludjerovic J, Komaba H, Sato T, Erben R, Baron R, Olauson H, et al.
FASEB J
. 2017 Feb;
31(5):2050-2064.
PMID: 28183805
Circulating levels of bone-derived fibroblast growth factor 23 (FGF23) increase early during acute and chronic kidney disease and are associated with adverse outcomes. Membrane-bound Klotho acts as a permissive coreceptor...
17.
Ide N, Olauson H, Sato T, Densmore M, Wang H, Hanai J, et al.
Kidney Int
. 2016 Jun;
90(2):348-362.
PMID: 27292223
Klotho is a transmembrane protein expressed in the renal tubules where it acts as a permissive coreceptor for fibroblast growth factor 23 (FGF23). FGF23 signaling reduces the abundance of CYP27b1...
18.
Fan Y, Bi R, Densmore M, Sato T, Kobayashi T, Yuan Q, et al.
FASEB J
. 2015 Oct;
30(1):428-40.
PMID: 26428657
Parathyroid-hormone-type 1 receptor (PTH1R) is extensively expressed in key regulatory organs for systemic mineral ion homeostasis, including kidney and bone. We investigated the bone-specific functions of PTH1R in modulating mineral...
19.
Olauson H, Lindberg K, Amin R, Sato T, Jia T, Goetz R, et al.
PLoS Genet
. 2013 Dec;
9(12):e1003975.
PMID: 24348262
Klotho acts as a co-receptor for and dictates tissue specificity of circulating FGF23. FGF23 inhibits PTH secretion, and reduced Klotho abundance is considered a pathogenic factor in renal secondary hyperparathyroidism....
20.
Yuan Q, Jiang Y, Zhao X, Sato T, Densmore M, Schuler C, et al.
J Bone Miner Res
. 2013 Sep;
29(3):693-704.
PMID: 24038141
Excessive FGF23 has been identified as a pivotal phosphaturic factor leading to renal phosphate-wasting and the subsequent development of rickets and osteomalacia. In contrast, loss of FGF23 in mice (Fgf23(-/-)...