T Scheuer
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Explore the profile of T Scheuer including associated specialties, affiliations and a list of published articles.
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86
Citations
4994
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Recent Articles
11.
McHugh D, Sharp E, Scheuer T, Catterall W
Proc Natl Acad Sci U S A
. 2000 Oct;
97(22):12334-8.
PMID: 11035786
We have investigated the mechanism underlying the modulation of the cardiac L-type Ca(2+) current by protein kinase C (PKC). Using the patch-clamp technique, we found that PKC activation by 4-alpha-phorbol...
12.
Yarov-Yarovoy V, Brown J, Sharp E, Clare J, Scheuer T, Catterall W
J Biol Chem
. 2000 Oct;
276(1):20-7.
PMID: 11024055
Mutations of amino acid residues in the inner two-thirds of the S6 segment in domain III of the rat brain type IIA Na(+) channel (G1460A to I1473A) caused periodic positive...
13.
Lee A, Scheuer T, Catterall W
J Neurosci
. 2000 Sep;
20(18):6830-8.
PMID: 10995827
Trains of action potentials cause Ca(2+)-dependent facilitation and inactivation of presynaptic P/Q-type Ca(2+) channels that can alter synaptic efficacy. A potential mechanism for these effects involves calmodulin, which associates in...
14.
Carter A, Grauert M, Pschorn U, Bechtel W, Qu Y, Scheuer T, et al.
Proc Natl Acad Sci U S A
. 2000 Apr;
97(9):4944-9.
PMID: 10781102
We have synthesized a new benzomorphan derivative, 2R-[2alpha,3(S*), 6alpha]-1,2,3,4,5,6-hexahydro-6,11, 11-trimethyl-3-[2-(phenylmethoxy)propyl]-2, 6-methano-3-benzazocin-10-ol hydrochloride (BIII 890 CL), which displaced [(3)H]batrachotoxinin A-20alpha-benzoate from neurotoxin receptor site 2 of the Na(+) channel in rat...
15.
Ratcliffe C, Qu Y, McCormick K, Tibbs V, Dixon J, Scheuer T, et al.
Nat Neurosci
. 2000 Apr;
3(5):437-44.
PMID: 10769382
Voltage-gated sodium channels in brain neurons were found to associate with receptor protein tyrosine phosphatase beta (RPTPbeta) and its catalytically inactive, secreted isoform phosphacan, and this interaction was regulated during...
16.
Weiser T, Qu Y, Catterall W, Scheuer T
Mol Pharmacol
. 1999 Nov;
56(6):1238-44.
PMID: 10570051
Mexiletine is a class I antiarrhythmic drug with neuroprotective effects in models of brain ischemia attributable to inhibition of brain sodium channels. We compared effects of R-mexiletine on wild-type and...
17.
Qu Y, Rogers J, Chen S, McCormick K, Scheuer T, Catterall W
J Biol Chem
. 1999 Nov;
274(46):32647-54.
PMID: 10551819
Voltage-gated sodium channels consist of a pore-forming alpha subunit associated with beta1 subunits and, for brain sodium channels, beta2 subunits. Although much is known about the structure and function of...
18.
McCormick K, Srinivasan J, White K, Scheuer T, Catterall W
J Biol Chem
. 1999 Nov;
274(46):32638-46.
PMID: 10551818
The type IIA voltage-gated sodium Na(+) channel from rat brain is composed of a large, pore-forming alpha subunit and the auxiliary subunits beta1 and beta2. When expressed in Xenopus oocytes,...
19.
Zhong H, Yokoyama C, Scheuer T, Catterall W
Nat Neurosci
. 1999 Oct;
2(11):939-41.
PMID: 10526329
No abstract available.
20.
Cantrell A, Tibbs V, Westenbroek R, Scheuer T, Catterall W
J Neurosci
. 1999 Aug;
19(17):RC21.
PMID: 10460275
Activation of D1-like dopamine (DA) receptors reduces peak Na(+) current in acutely isolated hippocampal neurons via a modulatory mechanism involving phosphorylation of the Na(+) channel alpha subunit by cAMP-dependent protein...