R Numann
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Explore the profile of R Numann including associated specialties, affiliations and a list of published articles.
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17
Citations
361
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Recent Articles
1.
Numann R, Negulescu P
Trends Cardiovasc Med
. 2001 Sep;
11(2):54-9.
PMID: 11530293
In this article we discuss new technologies for high-throughput screening (HTS) of cardiac ion channels. We review the current state of cell based HTS and discuss new technologies and approaches...
2.
Jow F, Numann R
J Membr Biol
. 2000 Jan;
173(2):107-16.
PMID: 10630926
We characterized the effects of histamine on intracellular Ca(2+) and activation of ionic currents in human capillary endothelial cells. Histamine produced both a transient and sustained increase in intracellular Ca(2+)....
3.
Jow B, Numann R
Eur J Pharmacol
. 1999 Dec;
383(2):197-202.
PMID: 10585534
The effect of the K(ATP) channel opener ZD6169 [(S)-N-(4-benzoyl-phenyl)-3,3, 3-trifluoro-2-hydroxy-2-methyl-propionamide] currently under development for the treatment of urinary incontinence was explored in acutely isolated adult feline ventricular myocytes. ZD6169 activated...
4.
Jow F, Numann R
J Membr Biol
. 1999 Sep;
171(2):127-39.
PMID: 10489425
Human aortic endothelial cells (HAEC) respond to flow with Ca2+ entry, activation of a nonselective cation channel, activation of a chloride channel, and activation of a calcium-activated potassium channel. Conversely,...
5.
6.
Dilks D, Ling H, Cockett M, Sokol P, Numann R
J Neurophysiol
. 1999 Apr;
81(4):1974-7.
PMID: 10200233
We report on the cloning and expression of hKv4.3, a fast inactivating, transient, A-type potassium channel found in both heart and brain that is 91% homologous to the rat Kv4.3...
7.
Jow F, Sullivan K, Sokol P, Numann R
J Membr Biol
. 1999 Jan;
167(1):53-64.
PMID: 9878075
Human capillary endothelial cells (HCEC) in normal media contain noninactivating outwardly rectifying chloride currents, TEA-sensitive delayed rectifier K+ currents and an inward rectifier K+ current. Two additional ionic currents are...
8.
Lo C, Numann R
Circ Res
. 1998 Nov;
83(10):995-1002.
PMID: 9815147
Expression of minK in Xenopus oocytes results in a current similar to the cardiac slow delayed rectifying K+ (IKs) current. Modulation of the IKs current in cardiac myocytes has been...
9.
Jow F, Numann R
J Physiol
. 1998 Sep;
512 ( Pt 1):119-28.
PMID: 9729622
1. Cultured human capillary endothelial cells (HCEC) contain a large inward rectifier current, IK(IR), that can be abolished by removing external K+ or by adding 50 microM Ba2+. 2. We...
10.
Zhang Z, Jow F, Numann R, Hinson J
Biochem Biophys Res Commun
. 1998 Mar;
244(1):50-6.
PMID: 9514862
Unlabelled: We studied the activation of a chloride channel in normal human bronchial epithelial cells (NHBE) by guanylin. We have observed a background Cl current (ICl,background) and a guanylin-induced outward...