T S Edgington
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Explore the profile of T S Edgington including associated specialties, affiliations and a list of published articles.
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251
Citations
4531
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Recent Articles
1.
Lin R, Maeda S, Liu C, Karin M, Edgington T
Oncogene
. 2006 Aug;
26(6):851-8.
PMID: 16878148
Tumor markers can facilitate understanding molecular cell biology of neoplasia and provide potential targets for the diagnosis and insight for intervention. We here identify a novel murine gene, hepcarcin (hcn),...
2.
Bookbinder L, Hofer A, Haller M, Zepeda M, Keller G, Lim J, et al.
J Control Release
. 2006 Aug;
114(2):230-41.
PMID: 16876899
Subcutaneously injected therapeutics must pass through the interstitial matrix of the skin in order to reach their intended targets. This complex, three-dimensional structure limits the type and quantity of drugs...
3.
Meisel S, Shechter M, Xu X, Edgington T, Cercek B, Shah P
Clin Lab Haematol
. 2003 Sep;
25(5):321-5.
PMID: 12974724
Monocytes express tissue factor (TF) as a result of cytokine stimulation or endothelial adherence. We evaluated monocyte-platelet interaction in vitro as another trigger for monocyte TF enhancement in human mononuclear...
4.
5.
Donate F, Kelly C, Ruf W, Edgington T
Biochemistry
. 2000 Sep;
39(37):11467-76.
PMID: 10985793
Tissue factor (TF) is a transmembrane receptor that initiates the thrombogenic cascade by assembly with the serine protease factor VII or VIIa (VII/VIIa) resulting in formation of the bimolecular active...
6.
7.
Meisel S, Shimon I, Edgington T, Melmed S, Cercek B, Shah P
Br J Haematol
. 1999 Dec;
107(4):747-55.
PMID: 10606879
Leukaemia inhibitory factor (LIF) and interleukin (IL)-6 are members of a cytokine group that share a common signal transducer gp130 and induce pleiotropic biological effects in cells of diverse lineage....
8.
Shobe J, Dickinson C, Edgington T, Ruf W
J Biol Chem
. 1999 Aug;
274(34):24171-5.
PMID: 10446191
The upstream coagulation enzymes are homologous trypsin-like serine proteases that typically function in enzyme-cofactor complexes, exemplified by coagulation factor VIIa (VIIa), which is allosterically activated upon binding to its cell...
9.
Ruf W, Shobe J, Rao S, Dickinson C, Olson A, Edgington T
Biochemistry
. 1999 Feb;
38(7):1957-66.
PMID: 10026279
Macromolecular substrate docking with coagulation enzyme-cofactor complexes involves multiple contacts distant from the enzyme's catalytic cleft. Here we characterize the binding of the Gla-domain of macromolecular substrate coagulation factor X...
10.
Huang M, Syed R, Stura E, Stone M, Stefanko R, Ruf W, et al.
J Mol Biol
. 1998 Mar;
275(5):873-94.
PMID: 9480775
The tissue factor (TF)-initiated blood coagulation protease cascade can be greatly inhibited in vivo by a potent anti-human-TF monoclonal antibody, 5G9. This antibody binds the carboxyl module of the extracellular...