Jeffrey Fillingham
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Explore the profile of Jeffrey Fillingham including associated specialties, affiliations and a list of published articles.
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30
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1763
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Recent Articles
1.
McNeil J, Lee S, Oliinyk A, Raina S, Garg J, Moallem M, et al.
EMBO Rep
. 2024 Jan;
25(1):68-81.
PMID: 38182817
The steady-state levels of protein sumoylation depend on relative rates of conjugation and desumoylation. Whether SUMO modifications are generally long-lasting or short-lived is unknown. Here we show that treating budding...
2.
Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, et al.
Epigenetics Chromatin
. 2023 Apr;
16(1):10.
PMID: 37024975
Background: Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of histone variants...
3.
Nabeel-Shah S, Garg J, Saettone A, Ashraf K, Lee H, Wahab S, et al.
Nucleic Acids Res
. 2021 Jun;
49(11):6196-6212.
PMID: 34086947
Retinoblastoma-binding proteins 4 and 7 (RBBP4 and RBBP7) are two highly homologous human histone chaperones. They function in epigenetic regulation as subunits of multiple chromatin-related complexes and have been implicated...
4.
Nabeel-Shah S, Garg J, Kougnassoukou Tchara P, Pearlman R, Lambert J, Fillingham J
STAR Protoc
. 2021 Mar;
2(1):100362.
PMID: 33786459
We describe an optimized protocol for one-step affinity purification of FZZ-tagged proteins followed by mass spectrometry analysis for the identification of protein-protein interactions in the ciliate protozoan . The FZZ...
5.
Wahab S, Saettone A, Nabeel-Shah S, Dannah N, Fillingham J
Front Cell Dev Biol
. 2020 Jul;
8:509.
PMID: 32695779
The eukaryotic histone acetylation cycle is composed of three classes of proteins, histone acetyltransferases (HATs) that add acetyl groups to lysine amino acids, bromodomain (BRD) containing proteins that are one...
6.
Nabeel-Shah S, Ashraf K, Saettone A, Garg J, Derynck J, Lambert J, et al.
Sci Rep
. 2020 Jan;
10(1):168.
PMID: 31932604
Chromatin organization influences most aspects of gene expression regulation. The linker histone H1, along with the core histones, is a key component of eukaryotic chromatin. Despite its critical roles in...
7.
Saettone A, Ponce M, Nabeel-Shah S, Fillingham J
BMC Bioinformatics
. 2019 Oct;
20(1):533.
PMID: 31664892
Background: Chromatin immunoprecipitation coupled to next generation sequencing (ChIP-Seq) is a widely-used molecular method to investigate the function of chromatin-related proteins by identifying their associated DNA sequences on a genomic...
8.
Garg J, Saettone A, Nabeel-Shah S, Cadorin M, Ponce M, Marquez S, et al.
Curr Biol
. 2019 Jul;
29(14):2371-2379.e6.
PMID: 31280994
Mediator is a large protein complex required for basal and regulated expression of most RNA polymerase II (RNAP II)-transcribed genes, in part due to its interaction with and phosphorylation of...
9.
Saettone A, Nabeel-Shah S, Garg J, Lambert J, Pearlman R, Fillingham J
Genes (Basel)
. 2019 May;
10(5).
PMID: 31052454
Identification and characterization of protein complexes and interactomes has been essential to the understanding of fundamental nuclear processes including transcription, replication, recombination, and maintenance of genome stability. Despite significant progress...
10.
Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras A, et al.
Mol Biol Evol
. 2019 Feb;
36(5):1037-1055.
PMID: 30796450
Epigenetic information, which can be passed on independently of the DNA sequence, is stored in part in the form of histone posttranslational modifications and specific histone variants. Although complexes necessary...