Suzanne L Jacques
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Explore the profile of Suzanne L Jacques including associated specialties, affiliations and a list of published articles.
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16
Citations
907
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Recent Articles
1.
Thomenius M, Totman J, Harvey D, Mitchell L, Riera T, Cosmopoulos K, et al.
PLoS One
. 2018 Jun;
13(6):e0197372.
PMID: 29856759
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular...
2.
Drew A, Moradei O, Jacques S, Rioux N, Boriack-Sjodin A, Allain C, et al.
Sci Rep
. 2017 Dec;
7(1):17993.
PMID: 29269946
CARM1 is an arginine methyltransferase with diverse histone and non-histone substrates implicated in the regulation of cellular processes including transcriptional co-activation and RNA processing. CARM1 overexpression has been reported in...
3.
Mitchell L, Boriack-Sjodin P, Smith S, Thomenius M, Rioux N, Munchhof M, et al.
ACS Med Chem Lett
. 2016 Mar;
7(2):134-8.
PMID: 26985287
SMYD3 has been implicated in a range of cancers; however, until now no potent selective small molecule inhibitors have been available for target validation studies. A novel oxindole series of...
4.
Jacques S, Aquino K, Gureasko J, Boriack-Sjodin P, Scott M, Copeland R, et al.
Biochemistry
. 2016 Feb;
55(11):1635-44.
PMID: 26848779
CARM1 is a type I arginine methyltransferase involved in the regulation of transcription, pre-mRNA splicing, cell cycle progression, and the DNA damage response. CARM1 overexpression has been implicated in breast,...
5.
Boriack-Sjodin P, Jin L, Jacques S, Drew A, Sneeringer C, Scott M, et al.
ACS Chem Biol
. 2015 Nov;
11(3):763-71.
PMID: 26551522
Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine N-methyltransferase (PRMT) enzyme that has been implicated in a variety of cancers. CARM1 is known to methylate histone H3 and nonhistone...
6.
Mitchell L, Drew A, Ribich S, Rioux N, Swinger K, Jacques S, et al.
ACS Med Chem Lett
. 2015 Jun;
6(6):655-9.
PMID: 26101569
A novel aryl pyrazole series of arginine methyltransferase inhibitors has been identified. Synthesis of analogues within this series yielded the first potent, selective, small molecule PRMT6 inhibitor tool compound, EPZ020411....
7.
Chan-Penebre E, Kuplast K, Majer C, Boriack-Sjodin P, Wigle T, Johnston L, et al.
Nat Chem Biol
. 2015 Apr;
11(6):432-7.
PMID: 25915199
Protein arginine methyltransferase-5 (PRMT5) is reported to have a role in diverse cellular processes, including tumorigenesis, and its overexpression is observed in cell lines and primary patient samples derived from...
8.
Tressel S, Koukos G, Tchernychev B, Jacques S, Covic L, Kuliopulos A
Methods Mol Biol
. 2010 Nov;
683:259-75.
PMID: 21053136
G protein-coupled receptors (GPCR) are a superfamily of receptors that are vital in a wide array of physiological processes. Modulation of GPCR signaling has been an intensive area of therapeutic...
9.
Liu H, Kuhn C, Feru F, Jacques S, Deshmukh G, Ye P, et al.
Bioorg Med Chem Lett
. 2010 Jul;
20(16):4885-91.
PMID: 20620059
By targeting an extended region of the conventional 'DFG-out' pocket of p38alpha, while minimizing interactions with the specificity pocket and eliminating interactions with the adenine binding site, we are able...
10.
DiNitto J, Deshmukh G, Zhang Y, Jacques S, Coli R, Worrall J, et al.
J Biochem
. 2010 Feb;
147(4):601-9.
PMID: 20147452
The activation of receptor tyrosine kinases (RTKs) is tightly regulated through a variety of mechanisms. Kinetic studies show that activation of c-Kit RTK occurs through an inter-molecular autophosphorylation. Phosphopeptide mapping...