P Ann Boriack-Sjodin
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Explore the profile of P Ann Boriack-Sjodin including associated specialties, affiliations and a list of published articles.
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42
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1408
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Recent Articles
1.
Castro J, Daniels M, Brennan D, Johnston B, Gotur D, Lee Y, et al.
Cancer Res
. 2024 Nov;
85(4):758-776.
PMID: 39589774
DHX9 is a multifunctional DExH-box RNA helicase with important roles in the regulation of transcription, translation, and maintenance of genome stability. Elevated expression of DHX9 is evident in multiple cancer...
2.
Lee Y, Sickmier E, Grigoriu S, Castro J, Boriack-Sjodin P
Acta Crystallogr D Struct Biol
. 2023 Oct;
79(Pt 11):980-991.
PMID: 37860960
DHX9 is a DExH-box RNA helicase with versatile functions in transcription, translation, RNA processing and regulation of DNA replication. DHX9 has recently emerged as a promising target for oncology, but...
3.
Gotur D, Case A, Liu J, Sickmier E, Holt N, Knockenhauer K, et al.
SLAS Discov
. 2023 Aug;
28(8):376-384.
PMID: 37625785
DHX9 is a DExH-box RNA helicase that utilizes hydrolysis of all four nucleotide triphosphates (NTPs) to power cycles of 3' to 5' directional movement to resolve and/or unwind double stranded...
4.
Buker S, Gurard-Levin Z, Wheeler B, Scholle M, Case A, Hirsch J, et al.
SLAS Discov
. 2019 Oct;
25(4):361-371.
PMID: 31585521
A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation. Methylation of adenosine at the N6 position (mA) in messenger RNA...
5.
Buker S, Boriack-Sjodin P, Copeland R
SLAS Discov
. 2019 Feb;
24(5):515-522.
PMID: 30811960
Contemporary chemical biology and drug discovery are increasingly focused on the discovery of inhibitory molecules that interact with enzyme targets in specific ways, such as allosteric or orthosteric binding. Hence,...
6.
Thomenius M, Totman J, Harvey D, Mitchell L, Riera T, Cosmopoulos K, et al.
PLoS One
. 2018 Jun;
13(6):e0197372.
PMID: 29856759
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular...
7.
Boriack-Sjodin P, Ribich S, Copeland R
Nat Rev Drug Discov
. 2018 May;
17(6):435-453.
PMID: 29773918
All major biological macromolecules (DNA, RNA, proteins and lipids) undergo enzyme-catalysed covalent modifications that impact their structure, function and stability. A variety of covalent modifications of RNA have been identified...
8.
Morrison M, Boriack-Sjodin P, Swinger K, Wigle T, Sadalge D, Kuntz K, et al.
PLoS One
. 2018 May;
13(5):e0197082.
PMID: 29742153
WHSC1 is a histone methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3 and has been implicated as a driver in a variety of hematological...
9.
Copeland R, Boriack-Sjodin P
Cell Chem Biol
. 2017 Dec;
25(2):128-134.
PMID: 29233521
A causal relationship between target activity modulation by small molecules and phenotypic consequence is the cornerstone of chemical biology and drug discovery. Here we articulate elements of translational chemical biology,...
10.
Duncan K, Rioux N, Boriack-Sjodin P, Munchhof M, Reiter L, Majer C, et al.
ACS Med Chem Lett
. 2016 Mar;
7(2):162-6.
PMID: 26985292
The recent publication of a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) provides the scientific community with in vivo-active tool compound EPZ015666 (GSK3235025) to probe the underlying pharmacology...