Suzanne Claxton
Overview
Explore the profile of Suzanne Claxton including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
562
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Recent Articles
1.
Silvestre M, Dempster K, Mihaylov S, Claxton S, Ultanir S
Mol Psychiatry
. 2024 Feb;
29(6):1844-1856.
PMID: 38326557
CDKL5 is a brain-enriched serine/threonine kinase, associated with a profound developmental and epileptic encephalopathy called CDKL5 deficiency disorder (CDD). To design targeted therapies for CDD, it is essential to determine...
2.
Sampedro-Castaneda M, Baltussen L, Lopes A, Qiu Y, Sirvio L, Mihaylov S, et al.
Nat Commun
. 2023 Dec;
14(1):7830.
PMID: 38081835
Developmental and epileptic encephalopathies (DEEs) are a group of rare childhood disorders characterized by severe epilepsy and cognitive deficits. Numerous DEE genes have been discovered thanks to advances in genomic...
3.
Rosianu F, Mihaylov S, Eder N, Martiniuc A, Claxton S, Flynn H, et al.
Life Sci Alliance
. 2022 Nov;
6(2).
PMID: 36446521
Autophagy is essential for neuronal development and its deregulation contributes to neurodegenerative diseases. NDR1 and NDR2 are highly conserved kinases, implicated in neuronal development, mitochondrial health and autophagy, but how...
4.
Eder N, Roncaroli F, Domart M, Horswell S, Andreiuolo F, Flynn H, et al.
Nat Commun
. 2020 Sep;
11(1):4934.
PMID: 32985498
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
5.
Eder N, Roncaroli F, Domart M, Horswell S, Andreiuolo F, Flynn H, et al.
Nat Commun
. 2020 May;
11(1):2380.
PMID: 32404936
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using...
6.
Lin A, Gill K, Sampedro Castaneda M, Matucci I, Eder N, Claxton S, et al.
Life Sci Alliance
. 2019 Jan;
1(6):e201800118.
PMID: 30623173
Cyclin G-associated kinase (GAK) is a ubiquitous serine/threonine kinase that facilitates clathrin uncoating during vesicle trafficking. GAK phosphorylates a coat adaptor component, AP2M1, to help achieve this function. GAK is...
7.
Baltussen L, Negraes P, Silvestre M, Claxton S, Moeskops M, Christodoulou E, et al.
EMBO J
. 2018 Sep;
37(24).
PMID: 30266824
Loss-of-function mutations in CDKL5 kinase cause severe neurodevelopmental delay and early-onset seizures. Identification of CDKL5 substrates is key to understanding its function. Using chemical genetics, we found that CDKL5 phosphorylates...
8.
Ultanir S, Yadav S, Hertz N, Oses-Prieto J, Claxton S, Burlingame A, et al.
Neuron
. 2014 Dec;
84(5):968-82.
PMID: 25456499
Mammalian Sterile 20 (Ste20)-like kinase 3 (MST3) is a ubiquitously expressed kinase capable of enhancing axon outgrowth. Whether and how MST3 kinase signaling might regulate development of dendritic filopodia and...
9.
Anthwal N, Pelling M, Claxton S, Mellitzer G, Collin C, Kessaris N, et al.
Dis Model Mech
. 2013 May;
6(5):1133-45.
PMID: 23649822
The ventral hypothalamus acts to integrate visceral and systemic information to control energy balance. The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3) is required for pancreatic β-cell development and has been...
10.
Yan C, Levesque M, Claxton S, Johnson R, Ang S
J Neurosci
. 2011 Sep;
31(35):12413-25.
PMID: 21880902
LIM homeodomain transcription factors, Lmx1a and Lmx1b, are required for the development of midbrain dopaminergic (mDA) neurons. Lmx1b is required for the specification and maintenance of mDA neurons, primarily due...