Simeon R Mihaylov
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Explore the profile of Simeon R Mihaylov including associated specialties, affiliations and a list of published articles.
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10
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84
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Recent Articles
1.
Jiang J, Wilkinson B, Flores I, Hartel N, Mihaylov S, Clementel V, et al.
Front Mol Neurosci
. 2024 Apr;
17:1359154.
PMID: 38638602
A large number of synaptic proteins have been recurrently associated with complex brain disorders. One of these proteins, the Traf and Nck interacting kinase (TNIK), is a postsynaptic density (PSD)...
2.
Silvestre M, Dempster K, Mihaylov S, Claxton S, Ultanir S
Mol Psychiatry
. 2024 Feb;
29(6):1844-1856.
PMID: 38326557
CDKL5 is a brain-enriched serine/threonine kinase, associated with a profound developmental and epileptic encephalopathy called CDKL5 deficiency disorder (CDD). To design targeted therapies for CDD, it is essential to determine...
3.
Sampedro-Castaneda M, Baltussen L, Lopes A, Qiu Y, Sirvio L, Mihaylov S, et al.
Nat Commun
. 2023 Dec;
14(1):7830.
PMID: 38081835
Developmental and epileptic encephalopathies (DEEs) are a group of rare childhood disorders characterized by severe epilepsy and cognitive deficits. Numerous DEE genes have been discovered thanks to advances in genomic...
4.
Mihaylov S, Castelli L, Lin Y, Gul A, Soni N, Hastings C, et al.
Nat Commun
. 2023 Sep;
14(1):5496.
PMID: 37679383
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis, linking external stimuli to transcriptional co-activation of genes involved in adaptive and age-related pathways. The carboxyl-terminus encodes a...
5.
Baskaran P, Mihaylov S, Vinsland E, Shah K, Granat L, Ultanir S, et al.
J Biol Chem
. 2022 Dec;
299(1):102788.
PMID: 36509146
Mechanistic target of rapamycin (mTOR) is a protein kinase that integrates multiple inputs to regulate anabolic cellular processes. For example, mTOR complex 1 (mTORC1) has key functions in growth control,...
6.
Rosianu F, Mihaylov S, Eder N, Martiniuc A, Claxton S, Flynn H, et al.
Life Sci Alliance
. 2022 Nov;
6(2).
PMID: 36446521
Autophagy is essential for neuronal development and its deregulation contributes to neurodegenerative diseases. NDR1 and NDR2 are highly conserved kinases, implicated in neuronal development, mitochondrial health and autophagy, but how...
7.
Vinsland E, Baskaran P, Mihaylov S, Hobbs C, Wood H, Bouybayoune I, et al.
Sci Rep
. 2021 Aug;
11(1):16299.
PMID: 34381067
Correct orchestration of nervous system development is a profound challenge that involves coordination of complex molecular and cellular processes. Mechanistic target of rapamycin (mTOR) signaling is a key regulator of...
8.
Morgan S, Garwood C, Jennings L, Simpson J, Castelli L, Heath P, et al.
Eur J Neurosci
. 2018 May;
47(12):1444-1456.
PMID: 29738614
Occludin is a component of tight junctions, which are essential structural components of the blood-brain barrier. However, occludin is expressed in cells without tight junctions, implying additional functions. We determined...
9.
Snijders A, Hautbergue G, Bloom A, Williamson J, Minshull T, Phillips H, et al.
RNA
. 2015 Jan;
21(3):347-59.
PMID: 25605962
Splicing factor proline- and glutamine-rich (SFPQ) also commonly known as polypyrimidine tract-binding protein-associated-splicing factor (PSF) and its binding partner non-POU domain-containing octamer-binding protein (NONO/p54nrb), are highly abundant, multifunctional nuclear proteins....
10.
Walsh M, Cooper-Knock J, Dodd J, Stopford M, Mihaylov S, Kirby J, et al.
Neuropathol Appl Neurobiol
. 2014 Oct;
41(2):109-34.
PMID: 25319671
Altered RNA metabolism is a key pathophysiological component causing several neurodegenerative diseases. Genetic mutations causing neurodegeneration occur in coding and noncoding regions of seemingly unrelated genes whose products do not...