Susana M Cerritelli
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Explore the profile of Susana M Cerritelli including associated specialties, affiliations and a list of published articles.
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25
Citations
1813
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Recent Articles
1.
Cerritelli S, Sakhuja K, Crouch R
Methods Mol Biol
. 2022 Jun;
2528:91-114.
PMID: 35704187
RNase H1 has become an essential tool to uncover the physiological and pathological roles of R-loops, three-stranded structures consisting of and RNA-DNA hybrid opposite to a single DNA strand (ssDNA)....
2.
Cerritelli S, El Hage A
Curr Genet
. 2020 Sep;
66(6):1073-1084.
PMID: 32886170
RNA/DNA hybrids are processed by RNases H1 and H2, while single ribonucleoside-monophosphates (rNMPs) embedded in genomic DNA are removed by the error-free, RNase H2-dependent ribonucleotide excision repair (RER) pathway. In...
3.
Cerritelli S, Iranzo J, Sharma S, Chabes A, Crouch R, Tollervey D, et al.
Nucleic Acids Res
. 2020 Mar;
48(8):4274-4297.
PMID: 32187369
Cellular levels of ribonucleoside triphosphates (rNTPs) are much higher than those of deoxyribonucleoside triphosphates (dNTPs), thereby influencing the frequency of incorporation of ribonucleoside monophosphates (rNMPs) by DNA polymerases (Pol) into...
4.
Cerritelli S, Crouch R
DNA Repair (Amst)
. 2019 Nov;
84:102736.
PMID: 31761672
Eukaryotic RNases H2 have dual functions in initiating the removal of ribonucleoside monophosphates (rNMPs) incorporated by DNA polymerases during DNA synthesis and in cleaving the RNA moiety of RNA/DNA hybrids...
5.
Cerritelli S, Crouch R
DNA Repair (Amst)
. 2019 Nov;
84:102742.
PMID: 31708455
No abstract available.
6.
Uehara R, Cerritelli S, Hasin N, Sakhuja K, London M, Iranzo J, et al.
Cell Rep
. 2018 Nov;
25(5):1135-1145.e5.
PMID: 30380406
RNase H2 has two distinct functions: initiation of the ribonucleotide excision repair (RER) pathway by cleaving ribonucleotides (rNMPs) incorporated during DNA replication and processing the RNA portion of an R-loop...
7.
Maul R, Chon H, Sakhuja K, Cerritelli S, Gugliotti L, Gearhart P, et al.
J Mol Biol
. 2017 Jan;
429(21):3255-3263.
PMID: 28065739
R-loops, three-strand structures consisting of mRNA hybridized to the complementary DNA and a single-stranded DNA loop, are formed in switch regions on the heavy-chain immunoglobulin locus. To determine if R-loops...
8.
Cerritelli S, Crouch R
Trends Biochem Sci
. 2016 Mar;
41(5):434-445.
PMID: 26996833
The abundance of ribonucleotides in DNA remained undetected until recently because they are efficiently removed by the ribonucleotide excision repair (RER) pathway, a process similar to Okazaki fragment (OF) processing...
9.
Pokatayev V, Hasin N, Chon H, Cerritelli S, Sakhuja K, Ward J, et al.
J Exp Med
. 2016 Feb;
213(3):329-36.
PMID: 26880576
The neuroinflammatory autoimmune disease Aicardi-Goutières syndrome (AGS) develops from mutations in genes encoding several nucleotide-processing proteins, including RNase H2. Defective RNase H2 may induce accumulation of self-nucleic acid species that...
10.
Donigan K, Cerritelli S, McDonald J, Vaisman A, Crouch R, Woodgate R
DNA Repair (Amst)
. 2015 Sep;
35:1-12.
PMID: 26340535
DNA polymerase η (pol η) is best characterized for its ability to perform accurate and efficient translesion DNA synthesis (TLS) through cyclobutane pyrimidine dimers (CPDs). To ensure accurate bypass the...