Hyongi Chon
Overview
Explore the profile of Hyongi Chon including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
855
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0
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Recent Articles
1.
Chon H, Kanamori S, Hibino K, Nagahara T, Suzuki T, Ohara K, et al.
Bioorg Med Chem Lett
. 2022 Dec;
80:129117.
PMID: 36584791
The conserved N-linked glycan at the Fc domain of recombinant monoclonal antibodies is an attractive target for site-specific payload conjugation for preparation of homogenous antibody-drug conjugates (ADCs). Here, we report...
2.
Uehara R, Cerritelli S, Hasin N, Sakhuja K, London M, Iranzo J, et al.
Cell Rep
. 2018 Nov;
25(5):1135-1145.e5.
PMID: 30380406
RNase H2 has two distinct functions: initiation of the ribonucleotide excision repair (RER) pathway by cleaving ribonucleotides (rNMPs) incorporated during DNA replication and processing the RNA portion of an R-loop...
3.
Malfatti M, Balachander S, Antoniali G, Koh K, Saint-Pierre C, Gasparutto D, et al.
Nucleic Acids Res
. 2017 Oct;
45(19):11193-11212.
PMID: 28977421
Ribonucleoside 5'-monophosphates (rNMPs) are the most common non-standard nucleotides found in DNA of eukaryotic cells, with over 100 million rNMPs transiently incorporated in the mammalian genome per cell cycle. Human...
4.
Maul R, Chon H, Sakhuja K, Cerritelli S, Gugliotti L, Gearhart P, et al.
J Mol Biol
. 2017 Jan;
429(21):3255-3263.
PMID: 28065739
R-loops, three-strand structures consisting of mRNA hybridized to the complementary DNA and a single-stranded DNA loop, are formed in switch regions on the heavy-chain immunoglobulin locus. To determine if R-loops...
5.
Pokatayev V, Hasin N, Chon H, Cerritelli S, Sakhuja K, Ward J, et al.
J Exp Med
. 2016 Feb;
213(3):329-36.
PMID: 26880576
The neuroinflammatory autoimmune disease Aicardi-Goutières syndrome (AGS) develops from mutations in genes encoding several nucleotide-processing proteins, including RNase H2. Defective RNase H2 may induce accumulation of self-nucleic acid species that...
6.
Gaidamakov S, Maximova O, Chon H, Blewett N, Wang H, Crawford A, et al.
Mol Cell Biol
. 2013 Nov;
34(1):123-31.
PMID: 24190965
La antigen (Sjögren's syndrome antigen B) is a phosphoprotein associated with nascent precursor tRNAs and other RNAs, and it is targeted by autoantibodies in patients with Sjögren's syndrome, systemic lupus...
7.
Chon H, Sparks J, Rychlik M, Nowotny M, Burgers P, Crouch R, et al.
Nucleic Acids Res
. 2013 Jan;
41(5):3130-43.
PMID: 23355612
Ribonuclease H2 (RNase H2) protects genome integrity by its dual roles of resolving transcription-related R-loops and ribonucleotides incorporated in DNA during replication. To unlink these two functions, we generated a...
8.
Sparks J, Chon H, Cerritelli S, Kunkel T, Johansson E, Crouch R, et al.
Mol Cell
. 2012 Aug;
47(6):980-6.
PMID: 22864116
Ribonucleotides are incorporated into DNA by the replicative DNA polymerases at frequencies of about 2 per kb, which makes them by far the most abundant form of potential DNA damage...
9.
Cerritelli S, Chon H, Crouch R
Science
. 2011 Jun;
332(6037):1510-1.
PMID: 21700860
No abstract available.
10.
Figiel M, Chon H, Cerritelli S, Cybulska M, Crouch R, Nowotny M
J Biol Chem
. 2010 Dec;
286(12):10540-50.
PMID: 21177858
RNase H2 cleaves RNA sequences that are part of RNA/DNA hybrids or that are incorporated into DNA, thus, preventing genomic instability and the accumulation of aberrant nucleic acid, which in...