Susan L Mercer
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Explore the profile of Susan L Mercer including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
273
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Recent Articles
1.
Murphy M, Kumar P, Bradley A, Barton C, Deweese J, Mercer S
Bioorg Med Chem
. 2020 Oct;
28(22):115773.
PMID: 33035756
Etoposide is a widely-used anticancer agent that targets human type II topoisomerases. Evidence suggests that metabolism of etoposide in myeloid progenitor cells is associated with translocations involved in leukemia development....
2.
Murray J, Mercer S, Jackson K
Xenobiotica
. 2019 Mar;
50(2):209-222.
PMID: 30902024
1. Meperidine is an opioid analgesic that undergoes demethylation to form the neurotoxic metabolite normeperidine. Previous studies indicate that meperidine -demethylation is catalyzed by cytochrome P450 2B6 (CYP2B6), CYP3A4, and...
3.
Burns S, Cunningham C, Mercer S
ACS Chem Neurosci
. 2018 Jun;
9(10):2428-2437.
PMID: 29894151
Fentanyl rose to prominence as an alternative analgesic to morphine nearly 50 years ago; today, fentanyl has re-emerged as a dangerous recreational substance. The increased potency and analgesic effect of...
4.
Devereaux A, Mercer S, Cunningham C
ACS Chem Neurosci
. 2018 May;
9(10):2395-2407.
PMID: 29757600
As the major psychoactive agent in opium and direct precursor for heroin, morphine is a historically critical molecule in chemical neuroscience. A structurally complex phenanthrene alkaloid produced by Papaver somniferum,...
5.
Wilson J, Fief C, Jackson K, Mercer S, Deweese J
Chem Res Toxicol
. 2017 Dec;
31(2):137-144.
PMID: 29272108
Topoisomerase II is a critical enzyme in replication, transcription, and the regulation of chromatin topology. Several anticancer agents target topoisomerases in order to disrupt cell growth. Cannabidiol is a major...
6.
Miller L, Mercer S
Curr Pharm Teach Learn
. 2017 Dec;
9(3):405-414.
PMID: 29233278
Background And Purpose: To describe the design, implementation, and student perceptions of a Drugs of Abuse and Addiction elective course utilizing an integrated teaching model. Educational Activity And Setting: Third-year...
7.
Gibson E, King M, Mercer S, Deweese J
Chem Res Toxicol
. 2016 Aug;
29(9):1541-8.
PMID: 27533850
Topoisomerase II is an essential nuclear enzyme involved in regulating DNA topology to facilitate replication and cell division. Disruption of topoisomerase II function by chemotherapeutic agents is in use as...
8.
Regal K, Mercer S, Deweese J
Chem Res Toxicol
. 2014 Nov;
27(12):2044-51.
PMID: 25409338
Topoisomerases are essential enzymes that are involved in DNA metabolism. Topoisomerase II generates transient DNA strand breaks that are stabilized by anticancer drugs, such as doxorubicin, causing an accumulation of...
9.
Lindsey Jr R, Pendleton M, Ashley R, Mercer S, Deweese J, Osheroff N
Biochemistry
. 2014 Oct;
53(41):6595-602.
PMID: 25280269
Coordination between the N-terminal gate and the catalytic core of topoisomerase II allows the proper capture, cleavage, and transport of DNA during the catalytic cycle. Because the activities of these...
10.
Metcalf M, Rosicky A, Hassan H, Eddington N, Coop A, Cunningham C, et al.
Bioorg Med Chem Lett
. 2014 Jun;
24(15):3592-5.
PMID: 24915880
The efflux transporter protein P-glycoprotein (P-gp) is capable of affecting the central distribution of diverse neurotherapeutics, including opioid analgesics, through their active removal from the brain. P-gp located at the...