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Sunil Laxman

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Articles 55
Citations 934
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Recent Articles
1.
Khatri S, Das S, Singh A, Ahmad S, Kashiv M, Laxman S, et al.
FASEB J . 2025 Feb; 39(3):e70365. PMID: 39902884
Exercise impinges on almost all physiological processes at an organismal level and is a potent intervention to treat various diseases. Exercise performance is well established to display diurnal rhythm, peaking...
2.
Vengayil V, Niphadkar S, Adhikary S, Varahan S, Laxman S
Elife . 2024 Sep; 12. PMID: 39324403
Many cells in high glucose repress mitochondrial respiration, as observed in the Crabtree and Warburg effects. Our understanding of biochemical constraints for mitochondrial activation is limited. Using a screen, we...
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Kumar R, Zhang F, Niphadkar S, Onu C, Vijjamarri A, Greenberg M, et al.
bioRxiv . 2024 Sep; PMID: 39257769
Degradation of many yeast mRNAs involves decapping by the Dcp1:Dcp2 complex. Previous studies on decapping activators Edc3 and Scd6 suggested their limited roles in mRNA decay. RNA-seq analysis of mutants...
5.
Gupta R, Adhikary S, Dalpatraj N, Laxman S
Nat Commun . 2024 Aug; 15(1):7254. PMID: 39179593
Cells contain disparate amounts of distinct amino acids, each of which has different metabolic and chemical origins, but the supply cost vs demand requirements of each is unclear. Here, using...
6.
Racine L, Parmentier R, Niphadkar S, Chhun J, Martignoles J, Delhommeau F, et al.
Life Sci Alliance . 2024 May; 7(8). PMID: 38802246
A continuous supply of energy is an essential prerequisite for survival and represents the highest priority for the cell. We hypothesize that cell differentiation is a process of optimization of...
7.
Niphadkar S, Karinje L, Laxman S
PLoS Genet . 2024 Mar; 20(3):e1011202. PMID: 38452140
To sustain growth in changing nutrient conditions, cells reorganize outputs of metabolic networks and appropriately reallocate resources. Signaling by reversible protein phosphorylation can control such metabolic adaptations. In contrast to...
8.
Das M, Sreedharan S, Shee S, Malhotra N, Nandy M, Banerjee U, et al.
Sci Adv . 2023 Dec; 9(50):eadh2858. PMID: 38091389
Iron-sulfur (Fe-S) biogenesis requires multiprotein assembly systems, SUF and ISC, in most prokaryotes. () encodes a complete SUF system, the depletion of which was bactericidal. The ISC operon is truncated...
9.
Prasad A, Sreedharan S, Bakthavachalu B, Laxman S
PLoS Biol . 2023 Oct; 21(10):e3002342. PMID: 37874799
Upon water loss, some organisms pause their life cycles and escape death. While widespread in microbes, this is less common in animals. Aedes mosquitoes are vectors for viral diseases. Aedes...
10.
Shee S, Veetil R, Mohanraj K, Das M, Malhotra N, Bandopadhyay D, et al.
Elife . 2023 Aug; 12. PMID: 37642294
() is evolutionarily equipped to resist exogenous reactive oxygen species (ROS) but shows vulnerability to an increase in endogenous ROS (eROS). Since eROS is an unavoidable consequence of aerobic metabolism,...