Sriram Varahan
Overview
Explore the profile of Sriram Varahan including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
207
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Recent Articles
1.
Vengayil V, Niphadkar S, Adhikary S, Varahan S, Laxman S
Elife
. 2024 Sep;
12.
PMID: 39324403
Many cells in high glucose repress mitochondrial respiration, as observed in the Crabtree and Warburg effects. Our understanding of biochemical constraints for mitochondrial activation is limited. Using a screen, we...
2.
3.
Varahan S, Laxman S
Genetics
. 2021 Dec;
219(2).
PMID: 34849891
In fluctuating nutrient environments, isogenic microbial cells transition into "multicellular" communities composed of phenotypically heterogeneous cells, showing functional specialization. In fungi (such as budding yeast), phenotypic heterogeneity is often described...
4.
Varahan S, Sinha V, Walvekar A, Krishna S, Laxman S
Elife
. 2021 Sep;
10.
PMID: 34554088
No abstract available.
5.
Parthasarathy S, Wang X, Carr K, Varahan S, Hancock E, Hancock L
J Bacteriol
. 2021 Aug;
203(20):e0025821.
PMID: 34370556
Enterococcus faecalis is a gut commensal but transitions to a pathogenic state as a consequence of intestinal dysbiosis and/or the presence of indwelling medical devices, causing a wide range of...
6.
Keffeler E, Iyer V, Parthasarathy S, Ramsey M, Gorman M, Barke T, et al.
mBio
. 2021 May;
12(3).
PMID: 34006651
The alternative sigma factor σ has been shown to regulate the expression of a wide array of virulence-associated genes, as well as central metabolism, in bacterial pathogens. In Gram-positive organisms,...
7.
Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S
Elife
. 2020 Dec;
9.
PMID: 33331821
No abstract available.
8.
Varahan S, Sinha V, Walvekar A, Krishna S, Laxman S
Elife
. 2020 Sep;
9.
PMID: 32876564
Previously, we found that in glucose-limited colonies, metabolic constraints drive cells into groups exhibiting gluconeogenic or glycolytic states. In that study, threshold amounts of trehalose - a limiting, produced carbon-resource,...
9.
Parthasarathy S, Jordan L, Schwarting N, Woods M, Abdullahi Z, Varahan S, et al.
J Bacteriol
. 2020 Jun;
202(17).
PMID: 32540933
is an opportunistic pathogen capable of causing infections, including endocarditis and urinary tract infections (UTI). One of the well-characterized quorum-sensing pathways in involves coordination of the conjugal transfer of pheromone-responsive...
10.
Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S
Elife
. 2019 Jun;
8.
PMID: 31241462
How phenotypically distinct states in isogenic cell populations appear and stably co-exist remains unresolved. We find that within a mature, clonal yeast colony developing in low glucose, cells arrange into...