Sumera Perveen
Overview
Explore the profile of Sumera Perveen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
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Articles
28
Citations
187
Followers
0
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Recent Articles
1.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Sci Rep
. 2025 Mar;
15(1):7264.
PMID: 40025188
Chikungunya is a mosquito-borne viral disease that causes fever and severe joint pain for which there is no direct acting drug treatments. Vinyl sulfone SGC-NSP2PRO-1 (3) was identified as a...
2.
Mettu A, Glavatskikh M, Wang X, Lara Ordonez A, Li F, Chau I, et al.
Chem Sci
. 2025 Jan;
16(8):3430-3439.
PMID: 39877816
Critical Assessment of Computational Hit-Finding Experiments (CACHE) Challenges emerged as real-life stress tests for computational hit-finding strategies. In CACHE Challenge #1, 23 participants contributed their original workflows to identify small-molecule...
3.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Res Sq
. 2024 Nov;
PMID: 39606462
RA-0003022 () was identified as a high-quality covalent chemical probe for nsP2 cysteine protease (nsP2pro). Isoxazole covalently captured the active site C478 and inactivated the enzyme with a / ratio...
4.
Li F, Ackloo S, Arrowsmith C, Ban F, Barden C, Beck H, et al.
J Chem Inf Model
. 2024 Nov;
64(22):8521-8536.
PMID: 39499532
The CACHE challenges are a series of prospective benchmarking exercises to evaluate progress in the field of computational hit-finding. Here we report the results of the inaugural CACHE challenge in...
5.
Ackloo S, Li F, Szewczyk M, Seitova A, Loppnau P, Zeng H, et al.
J Med Chem
. 2024 Nov;
68(2):1092-1112.
PMID: 39495097
Target class-focused drug discovery has a strong track record in pharmaceutical research, yet public domain data indicate that many members of protein families remain unliganded. Here we present a systematic...
6.
Merten E, Sears J, Leisner T, Hardy P, Ghoshal A, Hossain M, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(42):e2409166121.
PMID: 39388272
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has been responsible for numerous large-scale outbreaks in the last twenty years. Currently, there are no FDA-approved therapeutics for any alphavirus infection....
7.
Ghoshal A, Asressu K, Hossain M, Brown P, Nandakumar M, Vala A, et al.
J Med Chem
. 2024 Sep;
67(18):16505-16532.
PMID: 39235978
Despite their widespread impact on human health, there are no approved drugs for combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 () is a potent irreversible covalent inhibitor of...
8.
Eguida M, Bret G, Sindt F, Li F, Chau I, Ackloo S, et al.
J Chem Inf Model
. 2024 Jun;
64(13):5344-5355.
PMID: 38916159
We herewith applied a generic hit identification method (POEM) for difficult targets of known three-dimensional structure, relying on the simple knowledge of physicochemical and topological properties of a user-selected cavity....
9.
Ghoshal A, Asressu K, Hossain M, Brown P, Merten E, Sears J, et al.
bioRxiv
. 2024 Jun;
PMID: 38915519
Despite their widespread impact on human health there are no approved drugs for combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 () is a potent irreversible covalent inhibitor of...
10.
Yong D, Ahmad S, Mabanglo M, Halabelian L, Schapira M, Ackloo S, et al.
Biochemistry
. 2024 May;
63(10):1297-1306.
PMID: 38729622
The DNA damage binding protein 1 (DDB1) is an essential component of protein complexes involved in DNA damage repair and the ubiquitin-proteasome system (UPS) for protein degradation. As an adaptor...