Sumera Perveen
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Explore the profile of Sumera Perveen including associated specialties, affiliations and a list of published articles.
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28
Citations
187
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Recent Articles
11.
Merten E, Sears J, Leisner T, Hardy P, Ghoshal A, Hossain M, et al.
bioRxiv
. 2024 Apr;
PMID: 38562906
Significance Statement: Chikungunya virus is one of the most prominent and widespread alphaviruses and has caused explosive outbreaks of arthritic disease. Currently, there are no FDA-approved drugs to treat disease...
12.
Yazdi A, Perveen S, Dong C, Song X, Dong A, Szewczyk M, et al.
RSC Med Chem
. 2024 Mar;
15(3):1066-1071.
PMID: 38516600
We have developed a novel chemical handle (PFI-E3H1) and a chemical probe (PFI-7) as ligands for the Gid4 subunit of the human E3 ligase CTLH degradation complex. Through an efficient...
13.
Perveen S, Yazdi A, Hajian T, Li F, Vedadi M
Sci Rep
. 2024 Feb;
14(1):4509.
PMID: 38402266
The 5'-mRNA-cap formation is a conserved process in protection of mRNA in eukaryotic cells, resulting in mRNA stability and efficient translation. In humans, two methyltransferases, RNA cap guanine-N7 methyltransferase (hRNMT)...
14.
Zong Y, Weiss N, Wang K, Pagano A, Heissel S, Perveen S, et al.
Adv Sci (Weinh)
. 2024 Feb;
11(14):e2307526.
PMID: 38298064
Arginine and lysine, frequently appearing as a pair on histones, have been proven to carry diverse modifications and execute various epigenetic regulatory functions. However, the most context-specific and transient effectors...
15.
Kimani S, Perveen S, Szewezyk M, Zeng H, Dong A, Li F, et al.
Commun Biol
. 2023 Dec;
6(1):1272.
PMID: 38104184
Cbl-b is a RING-type E3 ubiquitin ligase that is expressed in several immune cell lineages, where it negatively regulates the activity of immune cells. Cbl-b has specifically been identified as...
16.
Nigam A, Hurley M, Li F, Konkolova E, Klima M, Trylcova J, et al.
bioRxiv
. 2023 Oct;
PMID: 37873443
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to significant global morbidity and mortality. A crucial viral protein, the non-structural protein 14 (nsp14), catalyzes the methylation of viral...
17.
Li F, Ghiabi P, Hajian T, Klima M, Li A, Yazdi A, et al.
Biochim Biophys Acta Gen Subj
. 2023 Feb;
1867(4):130319.
PMID: 36764586
Seven coronaviruses have infected humans (HCoVs) to-date. SARS-CoV-2 caused the current COVID-19 pandemic with the well-known high mortality and severe socioeconomic consequences. MERS-CoV and SARS-CoV caused epidemic of MERS and...
18.
Yazdi A, Pakarian P, Perveen S, Hajian T, Santhakumar V, Bolotokova A, et al.
ACS Infect Dis
. 2022 Jul;
8(8):1533-1542.
PMID: 35822715
SARS-CoV-2 non-structural protein 13 (nsp13) is a highly conserved helicase and RNA 5'-triphosphatase. It uses the energy derived from the hydrolysis of nucleoside triphosphates for directional movement along the nucleic...
19.
Devkota K, Schapira M, Perveen S, Yazdi A, Li F, Chau I, et al.
SLAS Discov
. 2021 Jul;
26(9):1200-1211.
PMID: 34192965
The COVID-19 pandemic has clearly brought the healthcare systems worldwide to a breaking point, along with devastating socioeconomic consequences. The SARS-CoV-2 virus, which causes the disease, uses RNA capping to...
20.
The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors
Otava T, Sala M, Li F, Fanfrlik J, Devkota K, Perveen S, et al.
ACS Infect Dis
. 2021 Jun;
7(8):2214-2220.
PMID: 34152728
In this study, we have focused on the structure-based design of the inhibitors of one of the two SARS-CoV-2 methyltransferases (MTases), nsp14. This MTase catalyzes the transfer of the methyl...