Suja Hiriyanna
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Explore the profile of Suja Hiriyanna including associated specialties, affiliations and a list of published articles.
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21
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925
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Recent Articles
1.
Yang W, Lee S, Lehmann O, Wu Z, Hiriyanna S, Swaroop A, et al.
Exp Eye Res
. 2023 Jul;
234:109599.
PMID: 37488009
Limbal epithelial stem cells are not only critical for corneal epithelial homeostasis but also have the capacity to change from a relatively quiescent mitotic phenotype to a rapidly proliferating cell...
2.
Kruczek K, Qu Z, Welby E, Shimada H, Hiriyanna S, English M, et al.
Stem Cell Reports
. 2022 Sep;
17(10):2172-2186.
PMID: 36084637
Mutations in the IQ calmodulin-binding motif containing B1 (IQCB1)/NPHP5 gene encoding the ciliary protein nephrocystin 5 cause early-onset blinding disease Leber congenital amaurosis (LCA), together with kidney dysfunction in Senior-Løken...
3.
Kruczek K, Qu Z, Gentry J, Fadl B, Gieser L, Hiriyanna S, et al.
Stem Cell Reports
. 2021 Jan;
16(2):252-263.
PMID: 33513359
Mutations in the photoreceptor transcription factor gene cone-rod homeobox (CRX) lead to distinct retinopathy phenotypes, including early-onset vision impairment in dominant Leber congenital amaurosis (LCA). Using induced pluripotent stem cells...
4.
Joe M, Li W, Hiriyanna S, Yu W, Shah S, Abu-Asab M, et al.
Hum Gene Ther
. 2019 Nov;
30(12):1520-1530.
PMID: 31672061
Identifying early disease hallmarks in animal models with slow disease progression may expedite disease detection and assessment of treatment outcomes. Using optical coherence tomography, a widely applied noninvasive method for...
5.
Mookherjee S, Chen H, Isgrig K, Yu W, Hiriyanna S, Levron R, et al.
Cell Rep
. 2018 Oct;
25(3):611-623.e6.
PMID: 30332642
Mutations in CEP290 cause ciliogenesis defects, leading to diverse clinical phenotypes, including Leber congenital amaurosis (LCA). Gene therapy for CEP290-associated diseases is hindered by the 7.4 kb CEP290 coding sequence,...
6.
Cukras C, Wiley H, Jeffrey B, Sen H, Turriff A, Zeng Y, et al.
Mol Ther
. 2018 Sep;
26(9):2282-2294.
PMID: 30196853
This study evaluated the safety and tolerability of ocular RS1 adeno-associated virus (AAV8-RS1) gene augmentation therapy to the retina of participants with X-linked retinoschisis (XLRS). XLRS is a monogenic trait...
7.
Sajgo S, Ghinia M, Brooks M, Kretschmer F, Chuang K, Hiriyanna S, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(20):E3974-E3983.
PMID: 28465430
Visual information is conveyed from the eye to the brain by distinct types of retinal ganglion cells (RGCs). It is largely unknown how RGCs acquire their defining morphological and physiological...
8.
Yu W, Mookherjee S, Chaitankar V, Hiriyanna S, Kim J, Brooks M, et al.
Nat Commun
. 2017 Mar;
8:14716.
PMID: 28291770
In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of cone function is a major therapeutic goal. However, cone loss is thought to occur as a secondary...
9.
A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction
Keenan W, Rupp A, Ross R, Somasundaram P, Hiriyanna S, Wu Z, et al.
Elife
. 2016 Sep;
5.
PMID: 27669145
Rapid and stable control of pupil size in response to light is critical for vision, but the neural coding mechanisms remain unclear. Here, we investigated the neural basis of pupil...
10.
Marangoni D, Bush R, Zeng Y, Wei L, Ziccardi L, Vijayasarathy C, et al.
Mol Ther Methods Clin Dev
. 2016 Sep;
5:16011.
PMID: 27626041
X-linked retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding the protein retinoschisin (RS1) and is one of the most common causes of macular degeneration in...