Paul A Sieving
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Explore the profile of Paul A Sieving including associated specialties, affiliations and a list of published articles.
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Articles
154
Citations
3848
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Recent Articles
1.
Smit-McBride Z, Sun N, Thomas S, Cho I, Stricklin R, Sieving P
Genes (Basel)
. 2025 Jan;
15(12.
PMID: 39766850
Background/objective: The Rs1 exon-1-del rat (Rs1KO) XLRS model shows normal retinal development until postnatal day 12 (P12) when small cystic spaces start to form in the inner nuclear layer. These...
2.
Zeng Y, Gao S, Li Y, Marangoni D, de Silva T, Wong W, et al.
Bioengineering (Basel)
. 2024 May;
11(5).
PMID: 38790316
Optical coherence tomography (OCT) is widely used to probe retinal structure and function. This study investigated the outer retina band (ORB) pattern and reflective intensity for the region between bands...
3.
Fadda A, Martelli F, Zein W, Jeffrey B, Placidi G, Sieving P, et al.
Invest Ophthalmol Vis Sci
. 2024 Apr;
65(4):3.
PMID: 38558093
Purpose: To describe and evaluate a novel method to determine the validity of measurements made using cycle-by-cycle (CxC) recording techniques in patients with advanced retinal degenerations (RD) having low-amplitude flicker...
4.
Wood E, Moshfeghi D, Capone Jr A, Williams G, Blumenkranz M, Sieving P, et al.
Ophthalmic Surg Lasers Imaging Retina
. 2023 Dec;
54(12):701-712.
PMID: 38113364
Michael T. Trese, MD (1946-2022), a vitreoretinal surgeon, made significant contributions to the field of retina. Although most known for his work in pediatric retina surgery, he was a pioneer...
5.
Ku C, Wei L, Sieving P
Cold Spring Harb Perspect Med
. 2023 Jan;
13(9).
PMID: 36690462
X-linked retinoschisis (XLRS) is an inherited vitreoretinal dystrophy causing visual impairment in males starting at a young age with an estimated prevalence of 1:5000 to 1:25,000. The condition was first...
6.
Sin T, Kim S, Li Y, Wang J, Chen R, Chung S, et al.
Invest Ophthalmol Vis Sci
. 2023 Jan;
64(1):18.
PMID: 36689233
Purpose: Foveoschisis involves the pathologic splitting of retinal layers at the fovea, which may occur congenitally in X-linked retinoschisis (XLRS) or as an acquired complication of myopia. XLRS is attributed...
7.
Heymann J, Vijayasarathy C, Fariss R, Sieving P
Prog Retin Eye Res
. 2022 Nov;
95:101147.
PMID: 36402656
Retinoschisin (RS1) is a secreted protein that is essential for maintaining integrity of the retina. Numerous mutations in RS1 cause X-linked retinoschisis (XLRS), a progressive degeneration of the retina that...
8.
Ye E, Zeng Y, Thomas S, Sun N, Smit-McBride Z, Sieving P
Genes (Basel)
. 2022 Nov;
13(11).
PMID: 36360232
We generated a Long Evans transgenic rat with targeted deletion of the whole Rs1 exon-1 and evaluated the pathological retinal phenotype of this rat model of X-linked retinoschisis (XLRS). The...
9.
Vijayasarathy C, Zeng Y, Marangoni D, Dong L, Pan Z, Simpson E, et al.
Invest Ophthalmol Vis Sci
. 2022 Oct;
63(11):8.
PMID: 36227606
Purpose: Loss of retinoschisin (RS1) function underlies X-linked retinoschisis (XLRS) pathology. In the retina, both photoreceptor inner segments and bipolar cells express RS1. However, the loss of RS1 function causes...
10.
Bender C, Woo E, Guan B, Ullah E, Feng E, Turriff A, et al.
Genes (Basel)
. 2022 Apr;
13(4).
PMID: 35456481
For disorders with X-linked inheritance, variants may be transmitted through multiple generations of carrier females before an affected male is ascertained. Pathogenic variants exclusively cause X-linked retinoschisis (XLRS). While is...