Lisa L Wei
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Explore the profile of Lisa L Wei including associated specialties, affiliations and a list of published articles.
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22
Citations
474
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Recent Articles
1.
Mishra A, Vijayasarathy C, Cukras C, Wiley H, Sen H, Zeng Y, et al.
Mol Ther
. 2021 Feb;
29(6):2030-2040.
PMID: 33601057
This study explored systemic immune changes in 11 subjects with X-linked retinoschisis (XLRS) in a phase I/IIa adeno-associated virus 8 (AAV8)-RS1 gene therapy trial (ClinicalTrials.gov: NCT02317887). Immune cell proportions and...
2.
Zeng Y, Boyd R, Bartoe J, Wiley H, Marangoni D, Wei L, et al.
Mol Ther Methods Clin Dev
. 2020 Jul;
18:422-427.
PMID: 32695844
Intravitreal administration for human adeno-associated vector (AAV) delivery is easier and less traumatic to ocular tissues than subretinal injection, but it gives limited retinal transduction. AAV vectors are large (about...
3.
Cukras C, Wiley H, Jeffrey B, Sen H, Turriff A, Zeng Y, et al.
Mol Ther
. 2018 Sep;
26(9):2282-2294.
PMID: 30196853
This study evaluated the safety and tolerability of ocular RS1 adeno-associated virus (AAV8-RS1) gene augmentation therapy to the retina of participants with X-linked retinoschisis (XLRS). XLRS is a monogenic trait...
4.
Marangoni D, Bush R, Zeng Y, Wei L, Ziccardi L, Vijayasarathy C, et al.
Mol Ther Methods Clin Dev
. 2016 Sep;
5:16011.
PMID: 27626041
X-linked retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding the protein retinoschisin (RS1) and is one of the most common causes of macular degeneration in...
5.
Marangoni D, Vijayasarathy C, Bush R, Wei L, Wen R, Sieving P
Invest Ophthalmol Vis Sci
. 2015 Nov;
56(11):6810-22.
PMID: 26567794
Purpose: Ciliary neurotrophic factor (CNTF) was recently shown to augment cone function in CNGB3 mutant achromat dogs. However, testing CNTF-releasing implant in human CNGB3 achromats failed to show benefit. We...
6.
Bush R, Wei L, Sieving P
Cold Spring Harb Perspect Med
. 2015 Jun;
5(8):a017368.
PMID: 26101206
Retinoschisis is an X-linked recessive genetic disease that leads to vision loss in males. X-linked retinoschisis (XLRS) typically affects young males; however, progressive vision loss continues throughout life. Although discovered...
7.
Ueyama K, Mori K, Shoji T, Omata H, Gehlbach P, Brough D, et al.
PLoS One
. 2014 Sep;
9(9):e108071.
PMID: 25232844
Purpose: To evaluate localization and transgene expression from adenoviral vector of serotypes 5, 35, and 28, ± an RGD motif in the fiber following intravitreal or subretinal administration. Methods: Ocular...
8.
Marangoni D, Wu Z, Wiley H, Zeiss C, Vijayasarathy C, Zeng Y, et al.
Hum Gene Ther Clin Dev
. 2014 Sep;
25(4):202-11.
PMID: 25211193
X-linked retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding the protein retinoschisin (RS1) and one of the most common causes of macular degeneration in young...
9.
Zein W, Jeffrey B, Wiley H, Turriff A, Tumminia S, Tao W, et al.
Invest Ophthalmol Vis Sci
. 2014 Sep;
55(10):6301-8.
PMID: 25205868
Purpose: Ciliary neurotrophic factor (CNTF) protects rod photoreceptors from retinal degenerative disease in multiple nonhuman models. Thus far, CNTF has failed to demonstrate rod protection in trials for human retinitis...
10.
Takita H, Yoneya S, Gehlbach P, Wei L, Mori K
J Ocul Biol Dis Infor
. 2010 Jan;
1(1):30-6.
PMID: 20072633
We have previously identified a neuroprotective effect associated with empty (E1(-), E3(-), E4(-)) adenovirus vector delivery in a model of light-induced, photoreceptor cell death. In this study, we further characterize...