Suja Hiriyanna

Overview

Explore the profile of Suja Hiriyanna including associated specialties, affiliations and a list of published articles.

Snapshot

Articles 21

Citations 925

Followers 0

Related Specialties

Genetics

Molecular Biology

Pharmacology

Top 10 Co-Authors

Zhijian Wu

Anand Swaroop

Peter Colosi

Paul A Sieving

Camasamudram Vijayasarathy

Yong Zeng

Tiansen Li

Ronald A Bush

Suddhasil Mookherjee

Lisa L Wei

Published In

Stem Cell Reports

Invest Ophthalmol Vis Sci

Hum Mol Genet

Hum Gene Ther

Am J Hum Genet

Affiliations

Soon will be listed here.

Recent Articles

11.

Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography

Zeng Y, Petralia R, Vijayasarathy C, Wu Z, Hiriyanna S, Song H, et al.

Invest Ophthalmol Vis Sci . 2016 Jul; 57(9):OCT277-87. PMID: 27409484

Purpose: Spectral-domain optical coherence tomography (SD-OCT) was used to characterize the retinal phenotype, natural history, and treatment responses in a mouse model of X-linked retinoschisis (Rs1-KO) and to identify new...

12.

Preclinical Dose-Escalation Study of Intravitreal AAV-RS1 Gene Therapy in a Mouse Model of X-linked Retinoschisis: Dose-Dependent Expression and Improved Retinal Structure and Function

Bush R, Zeng Y, Colosi P, Kjellstrom S, Hiriyanna S, Vijayasarathy C, et al.

Hum Gene Ther . 2016 Apr; 27(5):376-89. PMID: 27036983

Gene therapy for inherited retinal diseases has been shown to ameliorate functional and structural defects in both animal models and in human clinical trials. X-linked retinoschisis (XLRS) is an early-age...

13.

Long-term rescue of cone photoreceptor degeneration in retinitis pigmentosa 2 (RP2)-knockout mice by gene replacement therapy

Mookherjee S, Hiriyanna S, Kaneshiro K, Li L, Li Y, Li W, et al.

Hum Mol Genet . 2015 Sep; 24(22):6446-58. PMID: 26358772

Retinal neurodegenerative diseases are especially attractive targets for gene replacement therapy, which appears to be clinically effective for several monogenic diseases. X-linked forms of retinitis pigmentosa (XLRP) are relatively severe...

14.

A long-term efficacy study of gene replacement therapy for RPGR-associated retinal degeneration

Wu Z, Hiriyanna S, Qian H, Mookherjee S, Campos M, Gao C, et al.

Hum Mol Genet . 2015 Apr; 24(14):3956-70. PMID: 25877300

Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene account for >70% of X-linked retinitis pigmentosa (XLRP) and 15-20% of all inherited retinal degeneration. Gene replacement therapy for RPGR-XLRP was...

15.

Preclinical safety evaluation of a recombinant AAV8 vector for X-linked retinoschisis after intravitreal administration in rabbits

Marangoni D, Wu Z, Wiley H, Zeiss C, Vijayasarathy C, Zeng Y, et al.

Hum Gene Ther Clin Dev . 2014 Sep; 25(4):202-11. PMID: 25211193

X-linked retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding the protein retinoschisin (RS1) and one of the most common causes of macular degeneration in young...

16.

Rd9 is a naturally occurring mouse model of a common form of retinitis pigmentosa caused by mutations in RPGR-ORF15

Thompson D, Khan N, Othman M, Chang B, Jia L, Grahek G, et al.

PLoS One . 2012 May; 7(5):e35865. PMID: 22563472

Animal models of human disease are an invaluable component of studies aimed at understanding disease pathogenesis and therapeutic possibilities. Mutations in the gene encoding retinitis pigmentosa GTPase regulator (RPGR) are...

17.

Potent immune responses and in vitro pro-inflammatory cytokine suppression by a novel adenovirus vaccine vector based on rare human serotype 28

Kahl C, Bonnell J, Hiriyanna S, Fultz M, Nyberg-Hoffman C, Chen P, et al.

Vaccine . 2010 Jul; 28(35):5691-702. PMID: 20600496

Adenovirus vaccine vectors derived from rare human serotypes have been shown to be less potent than serotype 5 (Ad5) at inducing immune responses to encoded antigens. To identify highly immunogenic...

18.

Clinical studies of X-linked retinitis pigmentosa in three Swedish families with newly identified mutations in the RP2 and RPGR-ORF15 genes

Andreasson S, Breuer D, Eksandh L, Ponjavic V, Frennesson C, Hiriyanna S, et al.

Ophthalmic Genet . 2003 Oct; 24(4):215-23. PMID: 14566651

Purpose: To describe new disease-causing RP2 and RPGR-ORF15 mutations and their corresponding clinical phenotypes in Swedish families with X-linked retinitis pigmentosa (XLRP) and to establish genotype-phenotype correlations by studying the...

19.

Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing

Chao H, Mansfield S, Bartel R, Hiriyanna S, Mitchell L, Garcia-Blanco M, et al.

Nat Med . 2003 Jul; 9(8):1015-9. PMID: 12847523

Conventional gene therapy of hemophilia A relies on the transfer of factor VIII (FVIII; encoded by the F8 gene) cDNA. We carried out spliceosome-mediated RNA trans-splicing (SMaRT) to repair mutant...

20.

Microarray analysis of gene expression in the aging human retina

Yoshida S, Yashar B, Hiriyanna S, Swaroop A

Invest Ophthalmol Vis Sci . 2002 Jul; 43(8):2554-60. PMID: 12147584

Purpose: To develop gene expression profiles of young and elderly human retinas and identify candidate genes for aging-associated retinal diseases. Methods: Gene microarray slides containing 2400 human genes (primarily neuronal)...