Su Kit Chew
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Explore the profile of Su Kit Chew including associated specialties, affiliations and a list of published articles.
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11
Citations
716
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Recent Articles
1.
Hobor S, Al Bakir M, Hiley C, Skrzypski M, Frankell A, Bakker B, et al.
Nat Commun
. 2024 Jun;
15(1):4871.
PMID: 38871738
The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. Here,...
2.
Caswell D, Gui P, Mayekar M, Law E, Pich O, Bailey C, et al.
Nat Genet
. 2023 Dec;
56(1):60-73.
PMID: 38049664
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer was assessed. A3B expression in EGFR...
3.
Cai H, Chew S, Li C, Tsai M, Andrejka L, Murray C, et al.
Cancer Discov
. 2021 Feb;
11(7):1754-1773.
PMID: 33608386
Cancer genotyping has identified a large number of putative tumor suppressor genes. Carcinogenesis is a multistep process, but the importance and specific roles of many of these genes during tumor...
4.
Espana-Agusti J, Warren A, Chew S, Adams D, Matakidou A
Nat Commun
. 2017 Dec;
8(1):2026.
PMID: 29229903
Inactivation of the VHL (Von Hippel Lindau) tumour suppressor has long been recognised as necessary for the pathogenesis of clear cell renal cancer (ccRCC); however, the molecular mechanisms underlying transformation...
5.
Chew S, Lu D, Campos L, Scott K, Saci A, Wang J, et al.
Genome Biol
. 2014 Sep;
15(9):455.
PMID: 25260652
The in vivo validation of cancer mutations and genes identified in cancer genomics is resource-intensive because of the low throughput of animal experiments. We describe a mouse model that allows...
6.
Murugaesu N, Chew S, Swanton C
Am J Pathol
. 2013 May;
182(6):1962-71.
PMID: 23708210
Emerging evidence suggests that cancer branched evolution may affect biomarker validation, clinical outcome, and emergence of drug resistance. The changing spatial and temporal nature of cancer subclonal architecture during the...
7.
Burrell R, McClelland S, Endesfelder D, Groth P, Weller M, Shaikh N, et al.
Nature
. 2013 Mar;
494(7438):492-496.
PMID: 23446422
Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome number and structure and generates intratumour heterogeneity. CIN is observed in most solid tumours and is associated...
8.
Chew S, Rad R, Futreal P, Bradley A, Liu P
Methods
. 2010 Dec;
53(4):366-71.
PMID: 21185377
Transposons are an attractive system to use in genetic screens as they are molecularly tractable and the disrupted loci that give rise to the desired phenotype are easily mapped. We...
9.
Chew S, Chen P, Link N, Galindo K, Pogue K, Abrams J
Nature
. 2009 Jun;
460(7251):123-7.
PMID: 19483676
Apoptosis is a conserved form of programmed cell death firmly established in the aetiology, pathogenesis and treatment of many human diseases. Central to the core machinery of apoptosis are the...
10.
Chew S, Akdemir F, Chen P, Lu W, Mills K, Daish T, et al.
Dev Cell
. 2004 Dec;
7(6):897-907.
PMID: 15572131
Among the seven caspases encoded in the fly genome, only dronc contains a caspase recruitment domain. To assess the function of this gene in development, we produced a null mutation...