Eva Gronroos
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Explore the profile of Eva Gronroos including associated specialties, affiliations and a list of published articles.
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31
Citations
7593
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Recent Articles
1.
Lu W, Zalmas L, Bailey C, Black J, Martinez-Ruiz C, Pich O, et al.
Nat Cell Biol
. 2024 Dec;
27(1):154-168.
PMID: 39738653
Chromosomal instability (CIN) is common in solid tumours and fuels evolutionary adaptation and poor prognosis by increasing intratumour heterogeneity. Systematic characterization of driver events in the TRACERx non-small-cell lung cancer...
2.
Noorani I, Haughey M, Luebeck J, Rowan A, Gronroos E, Terenzi F, et al.
bioRxiv
. 2024 Nov;
PMID: 39484416
Highlights: ecDNA is the most common mechanism of focal oncogene amplification in wt glioblastoma. and its variants on ecDNA are particularly potent, likely arising early in tumor development, providing a...
3.
Hobor S, Al Bakir M, Hiley C, Skrzypski M, Frankell A, Bakker B, et al.
Nat Commun
. 2024 Jun;
15(1):4871.
PMID: 38871738
The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. Here,...
4.
Hynds R, Huebner A, Pearce D, Hill M, Akarca A, Moore D, et al.
Nat Commun
. 2024 May;
15(1):4653.
PMID: 38821942
Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients...
5.
Caswell D, Gui P, Mayekar M, Law E, Pich O, Bailey C, et al.
Nat Genet
. 2023 Dec;
56(1):60-73.
PMID: 38049664
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer was assessed. A3B expression in EGFR...
6.
Hennequart M, Pilley S, Labuschagne C, Coomes J, Mervant L, Driscoll P, et al.
Cell Rep
. 2023 May;
42(6):112562.
PMID: 37245210
Mitochondrial 10-formyltetrahydrofolate (10-formyl-THF) is utilized by three mitochondrial enzymes to produce formate for nucleotide synthesis, NADPH for antioxidant defense, and formyl-methionine (fMet) to initiate mitochondrial mRNA translation. One of these...
7.
Weeden C, Hill W, Lim E, Gronroos E, Swanton C
Cell
. 2023 Apr;
186(8):1541-1563.
PMID: 37059064
Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than previously appreciated. The human...
8.
Hill W, Lim E, Weeden C, Lee C, Augustine M, Chen K, et al.
Nature
. 2023 Apr;
616(7955):159-167.
PMID: 37020004
A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating...
9.
Grey W, Rio-Machin A, Casado P, Gronroos E, Ali S, Miettinen J, et al.
Sci Transl Med
. 2022 Jun;
14(650):eabn3248.
PMID: 35731890
Acute myeloid leukemia (AML) is an aggressive hematological disorder comprising a hierarchy of quiescent leukemic stem cells (LSCs) and proliferating blasts with limited self-renewal ability. AML has a dismal prognosis,...
10.
Venkatesan S, Angelova M, Puttick C, Zhai H, Caswell D, Lu W, et al.
Cancer Discov
. 2021 May;
11(10):2456-2473.
PMID: 33947663
APOBEC3 enzymes are cytosine deaminases implicated in cancer. Precisely when expression is induced during cancer development remains to be defined. Here we show that specific genes are upregulated in breast...