Stuart M Haslam
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Explore the profile of Stuart M Haslam including associated specialties, affiliations and a list of published articles.
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182
Citations
5926
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Recent Articles
1.
Li H, Tang X, Yang T, Liao T, Debowski A, Yang T, et al.
Gut Microbes
. 2025 Jan;
17(1):2455513.
PMID: 39834051
Protein glycosylation has been considered as a fundamental phenomenon shared by all domains of life. In , glycosylation of flagellins A and B with pseudaminic acid have been rigorously confirmed...
2.
Kundu S, Dos Santos Correia G, Lee Y, Ng S, Sykes L, Chan D, et al.
Microb Genom
. 2024 Dec;
10(12).
PMID: 39630497
Mutations in the gene that result in a lack of expression of histo-blood group antigens on secreted glycoproteins may shape the vaginal microbiota with consequences for birth outcome. To test...
3.
Wu G, Grassi P, Gimeno Molina B, MacIntyre D, Sykes L, Bennett P, et al.
Sci Rep
. 2024 Sep;
14(1):20813.
PMID: 39242814
During pregnancy the immune system needs to maintain immune tolerance of the foetus while also responding to infection, which can cause premature activation of the inflammatory pathways leading to the...
4.
Makrydaki E, Donini R, Krueger A, Royle K, Moya Ramirez I, Kuntz D, et al.
Nat Chem Biol
. 2024 Feb;
20(6):732-741.
PMID: 38321209
Glycosylation is a critical post-translational protein modification that affects folding, half-life and functionality. Glycosylation is a non-templated and heterogeneous process because of the promiscuity of the enzymes involved. We describe...
5.
Swaby C, Yeung-Luk B, Thapa S, Nishida K, Wally A, Ghosh B, et al.
bioRxiv
. 2023 Nov;
PMID: 37961411
COPD causes significant morbidity and mortality worldwide. Epithelial damage is fundamental to disease pathogenesis, although the mechanisms driving disease remain undefined. Published evidence from a COPD cohort (SPIROMICS) and confirmed...
6.
Sammon D, Krueger A, Busse-Wicher M, Morgan R, Haslam S, Schumann B, et al.
Nat Commun
. 2023 Oct;
14(1):6425.
PMID: 37828045
Two major glycosaminoglycan types, heparan sulfate (HS) and chondroitin sulfate (CS), control many aspects of development and physiology in a type-specific manner. HS and CS are attached to core proteins...
7.
Kikuchi C, Antonopoulos A, Wang S, Maemura T, Karamanska R, Lee C, et al.
Nat Commun
. 2023 Oct;
14(1):6178.
PMID: 37794004
Evolution of human H3N2 influenza viruses driven by immune selection has narrowed the receptor specificity of the hemagglutinin (HA) to a restricted subset of human-type (Neu5Acα2-6 Gal) glycan receptors that...
8.
Xie Y, Zhao F, Freitag N, Borowski S, Wang Y, Harms C, et al.
PNAS Nexus
. 2023 Aug;
2(8):pgad247.
PMID: 37575671
Placental abnormalities cause impaired fetal growth and poor pregnancy outcome (e.g. preeclampsia [PE]) with long-lasting consequences for the mother and offspring. The molecular dialogue between the maternal niche and the...
9.
Huang Z, Lai P, Cocker A, Haslam S, Dell A, Brady H, et al.
Biochem Soc Trans
. 2023 Mar;
51(2):639-653.
PMID: 36929183
Protein N-linked glycosylation is a structurally diverse post-translational modification that stores biological information in a larger order of magnitude than other post-translational modifications such as phosphorylation, ubiquitination and acetylation. This...
10.
Mohammed N, Antonopoulos A, Dell A, Haslam S, Dimitroff C
Adv Cancer Res
. 2023 Feb;
157:157-193.
PMID: 36725108
Melanoma is a highly aggressive skin cancer with poor outcomes associated with distant metastasis. Intrinsic properties of melanoma cells alongside the crosstalk between melanoma cells and surrounding microenvironment determine the...