Stuart M Haslam
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Explore the profile of Stuart M Haslam including associated specialties, affiliations and a list of published articles.
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182
Citations
5926
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Recent Articles
11.
Yung H, Zhao X, Glover L, Burrin C, Pang P, Jones C, et al.
iScience
. 2023 Jan;
26(1):105911.
PMID: 36660474
Placental hormones orchestrate maternal metabolic adaptations to support pregnancy. We hypothesized that placental ER stress, which characterizes early-onset pre-eclampsia (ePE), compromises glycosylation, reducing hormone bioactivity and these maladaptations predispose the...
12.
Kotidis P, Donini R, Arnsdorf J, Hansen A, Voldborg B, Chiang A, et al.
Metab Eng
. 2023 Jan;
76:87-96.
PMID: 36610518
Chinese hamster ovary (CHO) cells are extensively used for the production of glycoprotein therapeutics proteins, for which N-linked glycans are a critical quality attribute due to their influence on activity...
13.
Cioce A, Calle B, Rizou T, Lowery S, Bridgeman V, Mahoney K, et al.
Nat Commun
. 2022 Oct;
13(1):6237.
PMID: 36284108
Altered glycoprotein expression is an undisputed corollary of cancer development. Understanding these alterations is paramount but hampered by limitations underlying cellular model systems. For instance, the intricate interactions between tumour...
14.
Wu G, Grassi P, MacIntyre D, Gimeno Molina B, Sykes L, Kundu S, et al.
Sci Rep
. 2022 Oct;
12(1):16948.
PMID: 36216861
Human cervicovaginal fluid (CVF) is a complex, functionally important and glycan rich biological fluid, fundamental in mediating physiological events associated with reproductive health. Using a comprehensive glycomic strategy we reveal...
15.
Chakraborty A, Perez M, Carroll J, Antonopoulos A, Dell A, Ortega L, et al.
J Invest Dermatol
. 2022 Sep;
143(3):456-469.e8.
PMID: 36174713
The prognosis for patients with metastatic melanoma (MM) involving distant organs is grim, and treatment resistance is potentiated by tumor-initiating cells (TICs) that thrive under hypoxia. MM cells, including TICs,...
16.
Marbiah M, Kotidis P, Donini R, Gomez I, Jimenez Del Val I, Haslam S, et al.
J Vis Exp
. 2022 Jun;
(184).
PMID: 35723478
Recombinant monoclonal antibodies bind specific molecular targets and, subsequently, induce an immune response or inhibit the binding of other ligands. However, monoclonal antibody functionality and half-life may be reduced by...
17.
Duncombe L, Howells L, Haughey A, Taylor A, Kaveh D, Erdenlig Gyrbilek S, et al.
Microorganisms
. 2022 Apr;
10(4).
PMID: 35456759
Brucellosis is a global disease and the world's most prevalent zoonosis. All cases in livestock and most cases in humans are caused by members of the genus that possess a...
18.
Cao H, Mathur A, Robertson C, Antonopoulos A, Henderson S, Girard L, et al.
Br J Haematol
. 2022 Apr;
198(1):155-164.
PMID: 35411940
Red blood cells (RBCs) lose plasma membrane in the spleen as they age, but the cells and molecules involved are yet to be identified. Sickle cell disease and infection by...
19.
Wu G, Murugesan G, Nagala M, McCraw A, Haslam S, Dell A, et al.
Wellcome Open Res
. 2022 Feb;
6:134.
PMID: 35224210
: Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-dependent cellular interactions. Its upregulation on macrophages in autoimmune disease was shown previously to promote inflammation through suppressing the expansion...
20.
Edwards E, Livanos M, Krueger A, Dell A, Haslam S, Smales C, et al.
Biotechnol Bioeng
. 2022 Feb;
119(6):1343-1358.
PMID: 35182428
Glycosylation can be a critical quality attribute in biologic manufacturing. In particular, it has implications on the half-life, immunogenicity, and pharmacokinetics of therapeutic monoclonal antibodies (mAbs), and must be closely...