The Pleiotropic Role of Galectin-3 in Melanoma Progression: Unraveling the Enigma

Overview

Journal Adv Cancer Res

Publisher Elsevier

Specialty Oncology

Date 2023 Feb 1

PMID 36725108

Authors

Norhan B B Mohammed

Aristotelis Antonopoulos

Anne Dell

Stuart M Haslam

Charles J Dimitroff

Affiliations

Soon will be listed here.

Abstract

Melanoma is a highly aggressive skin cancer with poor outcomes associated with distant metastasis. Intrinsic properties of melanoma cells alongside the crosstalk between melanoma cells and surrounding microenvironment determine the tumor behavior. Galectin-3 (Gal-3), a ß-galactoside-binding lectin, has emerged as a major effector in cancer progression, including melanoma behavior. Data from melanoma models and patient studies reveal that Gal-3 expression is dysregulated, both intracellularly and extracellularly, throughout the stages of melanoma progression. This review summarizes the most recent data and hypotheses on Gal-3 and its tumor-modulating functions, highlighting its role in driving melanoma growth, invasion, and metastatic colonization. It also provides insight into potential Gal-3-targeted strategies for melanoma diagnosis and treatment.

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