Steven Watterson
Overview
Explore the profile of Steven Watterson including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
33
Citations
1263
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Recent Articles
21.
Parton A, McGilligan V, OKane M, Baldrick F, Watterson S
Brief Bioinform
. 2015 Oct;
17(4):562-75.
PMID: 26438419
Atherosclerosis is one of the principle pathologies of cardiovascular disease with blood cholesterol a significant risk factor. The World Health Organization estimates that approximately 2.5 million deaths occur annually because...
22.
Lu H, Talbot S, Robertson K, Watterson S, Forster T, Roy D, et al.
Steroids
. 2015 Mar;
99(Pt B):219-29.
PMID: 25759117
Interferons (IFNs) play a central role in immunity and emerging evidence suggests that IFN-signalling coordinately regulates sterol biosynthesis in macrophages, via Sterol Regulatory Element-Binding Protein (SREBP) dependent and independent pathways....
23.
Mazein A, Watterson S, Hsieh W, Griffiths W, Ghazal P
Biochem Pharmacol
. 2013 Apr;
86(1):56-66.
PMID: 23583456
Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how...
24.
Blanc M, Hsieh W, Robertson K, Kropp K, Forster T, Shui G, et al.
Immunity
. 2013 Jan;
38(1):106-18.
PMID: 23273843
Recent studies suggest that the sterol metabolic network participates in the interferon (IFN) antiviral response. However, the molecular mechanisms linking IFN with the sterol network and the identity of sterol...
25.
Watterson S, Guerriero M, Blanc M, Mazein A, Loewe L, Robertson K, et al.
Biochimie
. 2012 Jun;
95(3):613-21.
PMID: 22664637
The cholesterol biosynthesis pathway has recently been shown to play an important role in the innate immune response to viral infection with host protection occurring through a coordinate down regulation...
26.
Akman O, Watterson S, Parton A, Binns N, Millar A, Ghazal P
J R Soc Interface
. 2012 Apr;
9(74):2365-82.
PMID: 22499125
The gene networks that comprise the circadian clock modulate biological function across a range of scales, from gene expression to performance and adaptive behaviour. The clock functions by generating endogenous...
27.
Blanc M, Hsieh W, Robertson K, Watterson S, Shui G, Lacaze P, et al.
PLoS Biol
. 2011 Mar;
9(3):e1000598.
PMID: 21408089
Little is known about the protective role of inflammatory processes in modulating lipid metabolism in infection. Here we report an intimate link between the innate immune response to infection and...
28.
Ghazal P, Watterson S, Robertson K, Kluth D
Genome Med
. 2011 Feb;
3(1):4.
PMID: 21349141
Macrophages function as sentinel, cell-regulatory 'hubs' capable of initiating, perpetuating and contributing to the resolution of an inflammatory response, following their activation from a resting state. Highly complex and varied...
29.
Construction of a large scale integrated map of macrophage pathogen recognition and effector systems
Raza S, McDerment N, Lacaze P, Robertson K, Watterson S, Chen Y, et al.
BMC Syst Biol
. 2010 May;
4:63.
PMID: 20470404
Background: In an effort to better understand the molecular networks that underpin macrophage activation we have been assembling a map of relevant pathways. Manual curation of the published literature was...
30.
Watterson S, Ghazal P
Future Microbiol
. 2010 Feb;
5(2):163-76.
PMID: 20143942
Biological pathways link the molecular and cellular levels of biological activity and perform complex information processing seamlessly. Systems biology aims to combine an understanding of the cause-effect relationships of each...