Steven McKinney
Overview
Explore the profile of Steven McKinney including associated specialties, affiliations and a list of published articles.
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32
Citations
5583
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Recent Articles
1.
Funnell T, OFlanagan C, Williams M, McPherson A, McKinney S, Kabeer F, et al.
Nature
. 2022 Oct;
612(7938):106-115.
PMID: 36289342
How cell-to-cell copy number alterations that underpin genomic instability in human cancers drive genomic and phenotypic variation, and consequently the evolution of cancer, remains understudied. Here, by applying scaled single-cell...
2.
Eirew P, OFlanagan C, Ting J, Salehi S, Brimhall J, Wang B, et al.
Nat Commun
. 2022 Aug;
13(1):4534.
PMID: 35927228
Assessing tumour gene fitness in physiologically-relevant model systems is challenging due to biological features of in vivo tumour regeneration, including extreme variations in single cell lineage progeny. Here we develop...
3.
Osako T, Lee H, Turashvili G, Chiu D, McKinney S, Joosten S, et al.
Nat Cancer
. 2022 Feb;
1(5):518-532.
PMID: 35121983
The magnitude and scope of intrinsic age-correlated and host endocrine age-correlated gene expression in breast cancer is not well understood. From age-correlated gene expression in 3,071 breast cancer transcriptomes and...
4.
Masud T, Soong C, Xu H, Biele J, Bjornson S, McKinney S, et al.
Sci Rep
. 2021 May;
11(1):9812.
PMID: 33963218
CX-5461 is a G-quadruplex (G4) ligand currently in trials with initial indications of clinical activity in cancers with defects in homologous recombination repair. To identify more genetic defects that could...
5.
Rueda O, Sammut S, Seoane J, Chin S, Caswell-Jin J, Callari M, et al.
Nature
. 2019 Mar;
567(7748):399-404.
PMID: 30867590
The rates and routes of lethal systemic spread in breast cancer are poorly understood owing to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data. Long-term follow-up...
6.
Funnell T, Zhang A, Grewal D, McKinney S, Bashashati A, Wang Y, et al.
PLoS Comput Biol
. 2019 Feb;
15(2):e1006799.
PMID: 30794536
Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification and vulnerabilities to be exploited therapeutically. We present...
7.
Funnell T, Tasaki S, Oloumi A, Araki S, Kong E, Yap D, et al.
Nat Commun
. 2017 Feb;
8(1):7.
PMID: 28232751
CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent RNA processing events remains poorly defined. Here, we explore the connectivity...
8.
Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, ONeil N, et al.
Nat Commun
. 2017 Feb;
8:14432.
PMID: 28211448
G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very promising prospect. Here, we...
9.
Leung A, Hung S, Backstrom I, Ricaurte D, Kwok B, Poon S, et al.
PLoS One
. 2016 Mar;
11(3):e0150675.
PMID: 26938915
Platinum-based combination chemotherapy is the standard treatment for advanced non-small cell lung cancer (NSCLC). While cisplatin is effective, its use is not curative and resistance often emerges. As a consequence...
10.
El-Naggar A, Veinotte C, Cheng H, Grunewald T, Negri G, Somasekharan S, et al.
Cancer Cell
. 2015 May;
27(5):682-97.
PMID: 25965573
Metastatic dissemination is the leading cause of death in cancer patients, which is particularly evident for high-risk sarcomas such as Ewing sarcoma, osteosarcoma, and rhabdomyosarcoma. Previous research identified a crucial...