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Steven McKinney

Explore the profile of Steven McKinney including associated specialties, affiliations and a list of published articles. Areas
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Articles 32
Citations 5583
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Recent Articles
11.
Burleigh A, McKinney S, Brimhall J, Yap D, Eirew P, Poon S, et al.
Breast Cancer Res . 2015 Jan; 17:4. PMID: 25572802
Introduction: The extracellular signals regulating mammary epithelial cell growth are of relevance to understanding the pathophysiology of mammary epithelia, yet they remain poorly characterized. In this study, we applied an...
12.
Vollan H, Rueda O, Chin S, Curtis C, Turashvili G, Shah S, et al.
Mol Oncol . 2014 Aug; 9(1):115-27. PMID: 25169931
Complex focal chromosomal rearrangements in cancer genomes, also called "firestorms", can be scored from DNA copy number data. The complex arm-wise aberration index (CAAI) is a score that captures DNA...
13.
Xu H, Xian J, Vire E, McKinney S, Wei V, Wong J, et al.
J Pathol . 2014 Jul; 234(3):386-97. PMID: 25043256
BRCA2 mutations are significantly associated with early-onset breast cancer, and the tumour-suppressing function of BRCA2 has been attributed to its involvement in homologous recombination (HR)-mediated DNA repair. In order to...
14.
Silwal-Pandit L, Vollan H, Chin S, Rueda O, McKinney S, Osako T, et al.
Clin Cancer Res . 2014 May; 20(13):3569-80. PMID: 24803582
Purpose: In breast cancer, the TP53 gene is frequently mutated and the mutations have been associated with poor prognosis. The prognostic impact of the different types of TP53 mutations across...
15.
Cetinbas N, Huang-Hobbs H, Tognon C, Leprivier G, An J, McKinney S, et al.
J Biol Chem . 2013 Jun; 288(39):27940-50. PMID: 23798677
The ETV6-NTRK3 (EN) chimeric oncogene is expressed in diverse tumor types. EN is generated by a t(12;15) translocation, which fuses the N-terminal SAM (sterile α-motif) domain of the ETV6 (or...
16.
Curtis C, Shah S, Chin S, Turashvili G, Rueda O, Dunning M, et al.
Nature . 2012 Apr; 486(7403):346-52. PMID: 22522925
The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy...
17.
Yap D, Walker D, Prentice L, McKinney S, Turashvili G, Mooslehner-Allen K, et al.
PLoS One . 2011 Nov; 6(11):e27127. PMID: 22069496
Background: Mll5 is currently a member of the Mll family of SET domain histone methyltransferase proteins but studies have also showed that it could be part of the SET3 branch...
18.
Turashvili G, Yang W, McKinney S, Kalloger S, Gale N, Ng Y, et al.
Exp Mol Pathol . 2011 Oct; 92(1):33-43. PMID: 21963600
Although the extraction and analysis of nucleic acids from formalin-fixed paraffin-embedded tissues is a routine and growing part of pathology practice, no generally accepted recommendations exist to guide laboratories in...
19.
Prentice L, dAnglemont de Tassigny X, McKinney S, de Algara T, Yap D, Turashvili G, et al.
BMC Genomics . 2011 Apr; 12:209. PMID: 21527035
Background: Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated...
20.
Holland D, Burleigh A, Git A, Goldgraben M, Perez-Mancera P, Chin S, et al.
EMBO Mol Med . 2011 Feb; 3(3):167-80. PMID: 21337521
The telomeric amplicon at 8p12 is common in oestrogen receptor-positive (ER+) breast cancers. Array-CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within...