Leah M Prentice
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Explore the profile of Leah M Prentice including associated specialties, affiliations and a list of published articles.
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27
Citations
3270
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Recent Articles
1.
Handra J, Elbert A, Gazzaz N, Moller-Hansen A, Hyunh S, Lee H, et al.
Front Med (Lausanne)
. 2023 Jan;
9:1071348.
PMID: 36714130
Genomic medicine, an emerging medical discipline, applies the principles of evolution, developmental biology, functional genomics, and structural genomics within clinical care. Enabling widespread adoption and integration of genomic medicine into...
2.
Chin H, Gazzaz N, Huynh S, Handra I, Warnock L, Moller-Hansen A, et al.
Genet Med
. 2022 Apr;
24(7):1512-1522.
PMID: 35442193
Purpose: Genomic test results, regardless of laboratory variant classification, require clinical practitioners to judge the applicability of a variant for medical decisions. Teaching and standardizing clinical interpretation of genomic variation...
3.
Haile S, Nikiforuk A, Pandoh P, Twa D, Smailus D, Nguyen J, et al.
J Virol Methods
. 2021 Oct;
299:114339.
PMID: 34687784
The COVID-19 pandemic has highlighted the need for generic reagents and flexible systems in diagnostic testing. Magnetic bead-based nucleic acid extraction protocols using 96-well plates on open liquid handlers are...
4.
Tessier-Cloutier B, Kortekaas K, Thompson E, Pors J, Chen J, Ho J, et al.
Mod Pathol
. 2020 Mar;
33(8):1595-1605.
PMID: 32203095
The recent literature has shown that vulvar squamous cell carcinoma (VSCC) can be stratified into two prognostically relevant groups based on human papillomavirus (HPV) status. The prognostic value of p53...
5.
Melosky B, Bradbury P, Tu D, Florescu M, Reiman A, Nicholas G, et al.
Lung Cancer
. 2019 Jun;
133:48-55.
PMID: 31200828
Introduction: Activation of the RAS/RAF/MEK/ERK pathway may confer resistance to chemotherapy in non-small cell lung cancer (NSCLC). Selumetinib (AZD6244, ARRY142886), a MEK1/2 inhibitor combined with chemotherapy in patients with NSCLC...
6.
Prentice L, Miller R, Knaggs J, Mazloomian A, Aguirre Hernandez R, Franchini P, et al.
PLoS One
. 2018 Apr;
13(4):e0196434.
PMID: 29698444
Genomic analysis of cancer tissues is an essential aspect of personalized oncology treatment. Though it has been suggested that formalin fixation of patient tissues may be suboptimal for molecular studies,...
7.
Udo E, Furusato B, Sakai K, Prentice L, Tanaka T, Kitamura Y, et al.
Diagn Pathol
. 2017 Aug;
12(1):62.
PMID: 28830562
Background: Ciliated muconodular papillary tumors (CMPTs) are newly recognized rare peripheral lung nodules that are histologically characterized by ciliated columnar, goblet, and basal cells. Although recent studies have shown that...
8.
Wang Y, Bashashati A, Anglesio M, Cochrane D, Grewal D, Ha G, et al.
Nat Genet
. 2017 Apr;
49(6):856-865.
PMID: 28436987
We studied the whole-genome point mutation and structural variation patterns of 133 tumors (59 high-grade serous (HGSC), 35 clear cell (CCOC), 29 endometrioid (ENOC), and 10 adult granulosa cell (GCT))...
9.
McPherson A, Roth A, Laks E, Masud T, Bashashati A, Zhang A, et al.
Nat Genet
. 2016 May;
48(7):758-67.
PMID: 27182968
We performed phylogenetic analysis of high-grade serous ovarian cancers (68 samples from seven patients), identifying constituent clones and quantifying their relative abundances at multiple intraperitoneal sites. Through whole-genome and single-nucleus...
10.
Anglesio M, Bashashati A, Wang Y, Senz J, Ha G, Yang W, et al.
J Pathol
. 2015 Feb;
236(2):201-9.
PMID: 25692284
Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers and is often found contiguous with these cancers. Using whole-genome shotgun sequencing of seven clear cell ovarian...