Fa-Xiang Ding
Overview
Explore the profile of Fa-Xiang Ding including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
298
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0
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Recent Articles
1.
Dong S, Zhao Z, Tang H, Li G, Pan J, Gu X, et al.
J Med Chem
. 2024 Feb;
67(5):3400-3418.
PMID: 38387069
The use of β-lactam (BL) and β-lactamase inhibitor combination to overcome BL antibiotic resistance has been validated through clinically approved drug products. However, unmet medical needs still exist for the...
2.
Johns D, Campeau L, Banka P, Bautmans A, Bueters T, Bianchi E, et al.
Circulation
. 2023 May;
148(2):144-158.
PMID: 37125593
Background: Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9)-low density lipoprotein receptor interaction with injectable monoclonal antibodies or small interfering RNA lowers plasma low density lipoprotein-cholesterol, but despite nearly 2...
3.
Jiang J, Ding F, Zhou X, Bateman T, Dong S, Gu X, et al.
J Med Chem
. 2021 May;
64(11):7691-7701.
PMID: 34038119
A renal outer medullary potassium channel (ROMK, Kir1.1) is a putative drug target for a novel class of diuretics with potential for treating hypertension and heart failure. Our first disclosed...
4.
Zhu Y, de Jesus R, Tang H, Walsh S, Jiang J, Gu X, et al.
Bioorg Med Chem Lett
. 2016 Nov;
26(23):5695-5702.
PMID: 27839686
Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was identified. This series displays improved ROMK/hERG selectivity, and as a consequence, the resulting ROMK inhibitors...
5.
Cohen L, Arshava B, Kauffman S, Mathew E, Fracchiolla K, Ding F, et al.
Biopolymers
. 2013 Jul;
102(1):16-29.
PMID: 23897574
Structural analysis by NMR of G protein-coupled receptors (GPCRs) has proven to be extremely challenging. To reduce the number of peaks in the NMR spectra by segmentally labeling a GPCR,...
6.
Schnur E, Kessler N, Zherdev Y, Noah E, Scherf T, Ding F, et al.
FEBS J
. 2013 Mar;
280(9):2068-84.
PMID: 23480650
Chemokines constitute a large family of small proteins that regulate leukocyte trafficking to the site of inflammation by binding to specific cell-surface receptors belonging to the G-protein-coupled receptor (GPCR) superfamily....
7.
Moseri A, Tantry S, Ding F, Naider F, Anglister J
AIDS Res Hum Retroviruses
. 2012 Nov;
29(4):718-24.
PMID: 23176398
Due to the different mechanisms HIV-1 has evolved to escape from a neutralizing antibody response it has been extremely challenging to develop an effective anti-HIV-1 vaccine. The V3 region of...
8.
Mathew E, Ding F, Naider F, Dumont M
Protein Eng Des Sel
. 2012 Oct;
26(1):59-71.
PMID: 23077276
The insertion of a stable soluble protein into loops of transmembrane proteins has proved to be a successful approach for enhancing their stabilities and crystallization, and may also be useful...
9.
Shen H, Ding F, Jiang J, Verras A, Chabin R, Xu S, et al.
Bioorg Med Chem Lett
. 2012 Jan;
22(4):1550-6.
PMID: 22264488
A series of benzodihydroisofurans were discovered as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase (PrCP) inhibitors. The structure-activity relationship (SAR) is focused on improving PrCP activity and metabolic stability, and reducing...
10.
Schnur E, Noah E, Ayzenshtat I, Sargsyan H, Inui T, Ding F, et al.
J Mol Biol
. 2011 Jul;
410(5):778-97.
PMID: 21763489
Interaction of CC chemokine receptor 5 (CCR5) with the human immunodeficiency virus type 1 (HIV-1) gp120/CD4 complex involves its amino-terminal domain (Nt-CCR5) and requires sulfation of two to four tyrosine...