Steven K Nordeen
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Explore the profile of Steven K Nordeen including associated specialties, affiliations and a list of published articles.
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25
Citations
812
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Recent Articles
1.
Graham L, Su L, Nicklawsky A, Feng F, Orlicky D, Petraccione J, et al.
Cancers (Basel)
. 2025 Feb;
17(4).
PMID: 40002188
The use of supraphysiologic testosterone, particularly when alternated with an anti-androgen agent in men with metastatic castration-resistant prostate cancer (CRPC), has demonstrated promising results in clinical trials. As the use...
2.
Farrell K, Das S, Nordeen S, Lambert J, Thamm D
PLoS One
. 2024 May;
19(5):e0303470.
PMID: 38771847
VDX-111 (also identified as AMPI-109) is a vitamin D derivative which has shown anticancer activity. To further assess the function of this compound against multiple cancer types, we examined the...
3.
Nordeen S, Su L, Osborne G, Hayman P, Orlicky D, Wessells V, et al.
Life (Basel)
. 2021 Sep;
11(9).
PMID: 34575033
Since the Nobel Prize-winning work of Huggins, androgen ablation has been a mainstay for treatment of recurrent prostate cancer. While initially effective for most patients, prostate cancers inevitably develop the...
4.
Nordeen S, Bona B, Jones D, Lambert J, Jackson T
Horm Cancer
. 2013 Jul;
4(5):293-300.
PMID: 23836117
Dietary plant flavonoids have been proposed to contribute to cancer prevention, neuroprotection, and cardiovascular health through their anti-oxidant, anti-inflammatory, pro-apoptotic, and antiproliferative activities. As a consequence, flavonoid supplements are aggressively...
5.
Zhang C, Nordeen S, Shapiro D
Methods Mol Biol
. 2013 Feb;
977:339-51.
PMID: 23436375
Estrogens, acting via estrogen receptor (ER) play key roles in growth, differentiation, and gene regulation in the reproductive, central nervous, and skeletal systems. ER-mediated gene transcription contributes to the development...
6.
Aninye I, Berg K, Mollo A, Nordeen S, Wilson E, Shapiro D
Steroids
. 2012 Mar;
77(6):596-601.
PMID: 22421057
The progesterone receptor (PR) plays a key role in reproduction and is important in cancers of the reproductive tract. Current PR antagonists usually compete for progestin binding in the PR...
7.
Schaack J, Qiao L, Walkiewicz M, Stonehouse M, Engel D, Vazquez-Torres A, et al.
Virology
. 2011 Jan;
412(1):136-45.
PMID: 21272906
We have made improvements to E1-deleted adenovirus (Ad) transducing vectors that both substantially reduce the innate inflammatory response provoked by the virus in BALB/c mouse ears and increase the duration...
8.
Axlund S, Lambert J, Nordeen S
Mol Cancer Res
. 2010 Nov;
8(12):1643-55.
PMID: 21047772
HOX (homeobox) genes encode homeodomain-containing transcription factors critical to development, differentiation, and homeostasis. Their dysregulation has been implicated in a variety of cancers. Previously, we showed that a subset of...
9.
Kretzer N, Cherian M, Mao C, Aninye I, Reynolds P, Schiff R, et al.
J Biol Chem
. 2010 Nov;
285(53):41863-73.
PMID: 21041310
The mechanisms responsible for 17β-estradiol (E(2))-stimulated breast cancer growth and development of resistance to tamoxifen and other estrogen receptor α (ERα) antagonists are not fully understood. We describe a new...
10.
Zhang Y, Leung D, Nordeen S, Goleva E
J Biol Chem
. 2009 Jul;
284(36):24542-52.
PMID: 19586900
Although glucocorticoids suppress proliferation of many cell types and are used in the treatment of certain cancers, trials of glucocorticoid therapy in breast cancer have been a disappointment. Another suggestion...