Steven D Broadbent
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Explore the profile of Steven D Broadbent including associated specialties, affiliations and a list of published articles.
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5
Citations
52
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Recent Articles
1.
Akerman E, Read M, Bose S, Koschinski A, Capel R, Chao Y, et al.
Am J Physiol Heart Circ Physiol
. 2024 Aug;
327(4):H830-H846.
PMID: 39093001
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Excessive stimulation of the inositol (1,4,5)-trisphosphate (IP) signaling pathway has been linked to AF through abnormal calcium handling. However, little...
2.
Broadbent S, Ramjeesingh M, Bear C, Argent B, Linsdell P, Gray M
Pflugers Arch
. 2014 Oct;
467(8):1783-94.
PMID: 25277268
The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl(-) channel that governs the quantity and composition of epithelial secretions. CFTR function is normally tightly controlled as dysregulation can lead...
3.
Broadbent S, Wang W, Linsdell P
Biochem Cell Biol
. 2014 Sep;
92(5):390-6.
PMID: 25253636
Activity of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is thought to be controlled by cytoplasmic factors. However, recent evidence has shown that overall channel activity is also...
4.
Groot-Kormelink P, Broadbent S, Boorman J, Sivilotti L
J Gen Physiol
. 2004 May;
123(6):697-708.
PMID: 15148328
Tandem constructs are increasingly being used to restrict the composition of recombinant multimeric channels. It is therefore important to assess not only whether such approaches give functional channels, but also...
5.
Boorman J, Beato M, Groot-Kormelink P, Broadbent S, Sivilotti L
J Biol Chem
. 2003 Aug;
278(45):44033-40.
PMID: 12912995
We compared the main properties of human recombinant alpha3beta4beta3 neuronal nicotinic receptors with those of alpha3beta4 receptors, expressed in Xenopus oocytes. beta3 incorporation decreased the channel mean open time (from...