Lucia G Sivilotti
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Explore the profile of Lucia G Sivilotti including associated specialties, affiliations and a list of published articles.
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36
Citations
1086
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Recent Articles
1.
Alexander S, Mathie A, Peters J, Veale E, Striessnig J, Kelly E, et al.
Br J Pharmacol
. 2023 Dec;
180 Suppl 2:S145-S222.
PMID: 38123150
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
2.
Ivica J, Zhu H, Lape R, Gouaux E, Sivilotti L
Elife
. 2022 Aug;
11.
PMID: 35975975
To clarify the determinants of agonist efficacy in pentameric ligand-gated ion channels, we examined a new compound, aminomethanesulfonic acid (AMS), a molecule intermediate in structure between glycine and taurine. Despite...
3.
Ivica J, Lape R, Sivilotti L
J Physiol
. 2021 Nov;
600(2):333-347.
PMID: 34802146
Many pentameric ligand-gated ion channels are modulated by extracellular pH. Glycine receptors (GlyRs) share this property, but it is not well understood how they are affected by pH changes. Whole...
4.
Alexander S, Mathie A, Peters J, Veale E, Striessnig J, Kelly E, et al.
Br J Pharmacol
. 2021 Sep;
178 Suppl 1:S157-S245.
PMID: 34529831
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
5.
Ivica J, Lape R, Jazbec V, Yu J, Zhu H, Gouaux E, et al.
J Biol Chem
. 2021 Feb;
296:100387.
PMID: 33617876
Like other pentameric ligand-gated channels, glycine receptors (GlyRs) contain long intracellular domains (ICDs) between transmembrane helices 3 and 4. Structurally characterized GlyRs are generally engineered to have a very short...
6.
Wu Z, Lape R, Jopp-Saile L, OCallaghan B, Greiner T, Sivilotti L
J Physiol
. 2020 May;
598(16):3417-3438.
PMID: 32445491
Key Points: Loss-of-function mutations in proteins found at glycinergic synapses, most commonly in the α1 subunit of the glycine receptor (GlyR), cause the startle disease/hyperekplexia channelopathy in man. It was...
7.
Pless S, Sivilotti L
Curr Opin Physiol
. 2019 Jun;
2:19-26.
PMID: 31231710
Pentameric ligand-gated ion channels (pLGICs, also known as Cys-loop receptors) are a large family of ion channels expressed in all and in several groups of bacteria and archaea. They are...
8.
Safar F, Hurdiss E, Erotocritou M, Greiner T, Lape R, Irvine M, et al.
J Biol Chem
. 2017 Feb;
292(12):5031-5042.
PMID: 28174298
Glycine receptors (GlyR) belong to the pentameric ligand-gated ion channel (pLGIC) superfamily and mediate fast inhibitory transmission in the vertebrate CNS. Disruption of glycinergic transmission by inherited mutations produces startle...
9.
Groot-Kormelink P, Ferrand S, Kelley N, Bill A, Freuler F, Imbert P, et al.
PLoS One
. 2016 Sep;
11(9):e0163129.
PMID: 27649498
High throughput random mutagenesis is a powerful tool to identify which residues are important for the function of a protein, and gain insight into its structure-function relation. The human muscle...
10.
Epstein M, Calderhead B, Girolami M, Sivilotti L
Biophys J
. 2016 Jul;
111(2):333-348.
PMID: 27463136
The stochastic behavior of single ion channels is most often described as an aggregated continuous-time Markov process with discrete states. For ligand-gated channels each state can represent a different conformation...