Derek A Terrar
Overview
Explore the profile of Derek A Terrar including associated specialties, affiliations and a list of published articles.
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35
Citations
835
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Recent Articles
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Akerman E, Read M, Bose S, Koschinski A, Capel R, Chao Y, et al.
Am J Physiol Heart Circ Physiol
. 2024 Aug;
327(4):H830-H846.
PMID: 39093001
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Excessive stimulation of the inositol (1,4,5)-trisphosphate (IP) signaling pathway has been linked to AF through abnormal calcium handling. However, little...
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Burton R, Terrar D
Contact (Thousand Oaks)
. 2023 Jun;
4:25152564211008341.
PMID: 37366374
Calcium handling is vital to normal physiological function in the heart. Human atrial arrhythmias, eg. atrial fibrillation, are a major morbidity and mortality burden, yet major gaps remain in our...
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Terrar D
Philos Trans R Soc Lond B Biol Sci
. 2023 May;
378(1879):20220170.
PMID: 37122228
Rhythms of electrical activity in all regions of the heart can be influenced by a variety of intracellular membrane bound organelles. This is true both for normal pacemaker activity and...
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Ahmad F, Jin Y, Grassam-Rowe A, Zhou Y, Yuan M, Fan X, et al.
Philos Trans R Soc Lond B Biol Sci
. 2023 May;
378(1879):20220312.
PMID: 37122218
Atrial fibrillation (AF) is the most common chronic arrhythmia presenting a heavy disease burden. We report a new approach for generating cardiomyocytes (CMs) resembling atrial cells from human-induced pluripotent stem...
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Bose S, Read M, Akerman E, Capel R, Ayagama T, Russell A, et al.
Front Pharmacol
. 2022 Sep;
13:951897.
PMID: 36105228
Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP signalling pathway has been proposed as an atrial-specific target for...
8.
Terrar D
Cell Calcium
. 2022 Mar;
104:102565.
PMID: 35299075
Calcium ions play a central role in determining the timing and magnitude of the pumping action of heart muscle in a process which couples electrical activity of action potentials to...
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Capel R, Bose S, Collins T, Rajasundaram S, Ayagama T, Zaccolo M, et al.
Am J Physiol Heart Circ Physiol
. 2020 Oct;
320(1):H95-H107.
PMID: 33064562
Inositol trisphosphate (IP) is a Ca-mobilizing second messenger shown to modulate atrial muscle contraction and is thought to contribute to atrial fibrillation. Cellular pathways underlying IP actions in cardiac tissue...
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Terrar D
Adv Exp Med Biol
. 2019 Oct;
1131:395-443.
PMID: 31646519
The aim of this chapter is to discuss evidence concerning the many roles of calcium ions, Ca, in cell signaling pathways that control heart function. Before considering details of these...