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Steven A Vokes

Explore the profile of Steven A Vokes including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Norrie J, Li Q, Co S, Huang B, Ding D, Uy J, et al.
Development . 2016 Nov; 143(24):4608-4619. PMID: 27827819
During embryonic development, undifferentiated progenitor cells balance the generation of additional progenitor cells with differentiation. Within the developing limb, cartilage cells differentiate from mesodermal progenitors in an ordered process that...
12.
Huang B, Trofka A, Furusawa A, Norrie J, Rabinowitz A, Vokes S, et al.
Nat Commun . 2016 Oct; 7:12903. PMID: 27713395
The number of phalanges and joints are key features of digit 'identity' and are central to limb functionality and evolutionary adaptation. Prior chick work indicated that digit phalanges and their...
13.
Li Q, Lex R, Chung H, Giovanetti S, Ji Z, Ji H, et al.
J Biol Chem . 2016 Jan; 291(13):7171-82. PMID: 26797124
The Hedgehog (HH) signaling pathway is essential for the maintenance and response of several types of stem cells. To study the transcriptional response of stem cells to HH signaling, we...
14.
Ji Z, Vokes S, Dang C, Ji H
Nucleic Acids Res . 2015 Sep; 44(1):e8. PMID: 26350211
Gene Set Context Analysis (GSCA) is an open source software package to help researchers use massive amounts of publicly available gene expression data (PED) to make discoveries. Users can interactively...
15.
Lewandowski J, Du F, Zhang S, Powell M, Falkenstein K, Ji H, et al.
Dev Biol . 2015 Aug; 406(1):92-103. PMID: 26238476
GLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissue-specific fashion. The Shh pathway has been extensively studied in the limb bud, where it helps regulate...
16.
Hoffmann A, Yang X, Burnicka-Turek O, Bosman J, Ren X, Steimle J, et al.
PLoS Genet . 2014 Oct; 10(10):e1004604. PMID: 25356765
The Second Heart Field (SHF) has been implicated in several forms of congenital heart disease (CHD), including atrioventricular septal defects (AVSDs). Identifying the SHF gene regulatory networks required for atrioventricular...
17.
Norrie J, Lewandowski J, Bouldin C, Amarnath S, Li Q, Vokes M, et al.
Dev Biol . 2014 Jul; 393(2):270-281. PMID: 25034710
Mutations in the Bone Morphogenetic Protein (BMP) pathway are associated with a range of defects in skeletal formation. Genetic analysis of BMP signaling requirements is complicated by the presence of...
18.
Falkenstein K, Vokes S
Semin Cell Dev Biol . 2014 May; 33:73-80. PMID: 24862856
The Hedgehog (Hh) pathway plays conserved roles in regulating a diverse spectrum of developmental processes. In some developmental contexts, a gradient of Hh protein specifies multiple cell types in a...
19.
Li Q, Lewandowski J, Powell M, Norrie J, Cho S, Vokes S
Development . 2014 Apr; 141(9):1906-14. PMID: 24700818
The transcriptional response to the Hedgehog (Hh) pathway is mediated by Gli proteins, which function as context-dependent transcriptional activators or repressors. However, the mechanism by which Gli proteins regulate their...
20.
Lewandowski J, Pursell T, Rabinowitz A, Vokes S
Dev Dyn . 2014 Mar; 243(7):928-36. PMID: 24633820
Background: The vertebrate limb bud is a well-established system for studying the mechanisms driving growth and patterning of an embryonic tissue. However, approaches for manipulating gene expression are currently limited...