Wing H Wong
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Explore the profile of Wing H Wong including associated specialties, affiliations and a list of published articles.
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81
Citations
6121
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Recent Articles
1.
Zhou B, Arthur J, Guo H, Kim T, Huang Y, Pattni R, et al.
Cell
. 2024 Oct;
187(23):6687-6706.e25.
PMID: 39353437
Complex structural variations (cxSVs) are often overlooked in genome analyses due to detection challenges. We developed ARC-SV, a probabilistic and machine-learning-based method that enables accurate detection and reconstruction of cxSVs...
2.
Tan W, Seow W, Zhang A, Rhee S, Wong W, Greenleaf W, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(1):20-34.
PMID: 39196210
Single-cell technology has become an indispensable tool in cardiovascular research since its first introduction in 2009. Here, we highlight the recent remarkable progress in using single-cell technology to study transcriptomic...
3.
Zhou B, Purmann C, Guo H, Shin G, Huang Y, Pattni R, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(31):e2322834121.
PMID: 39042694
We developed a generally applicable method, CRISPR/Cas9-targeted long-read sequencing (CTLR-Seq), to resolve, haplotype-specifically, the large and complex regions in the human genome that had been previously impenetrable to sequencing analysis,...
4.
Lin Y, Wu T, Chen X, Wan S, Chao B, Xin J, et al.
Genome Res
. 2024 Jan;
34(1):119-133.
PMID: 38190633
Single-cell technologies offer unprecedented opportunities to dissect gene regulatory mechanisms in context-specific ways. Although there are computational methods for extracting gene regulatory relationships from scRNA-seq and scATAC-seq data, the data...
5.
Johnson N, London S, Romieu I, Wong W, Tang H
Stat Sin
. 2023 Jul;
23:1441-1461.
PMID: 37398638
Haplotype, or the sequence of alleles along a single chromosome, has important applications in phenotype-genotype association studies, as well as in population genetics analyses. Because haplotype cannot be experimentally assayed...
6.
Lin Y, Wu T, Chen X, Wan S, Chao B, Xin J, et al.
bioRxiv
. 2023 Jun;
PMID: 37292801
Single-cell technologies offer unprecedented opportunities to dissect gene regulatory mechanisms in context-specific ways. Although there are computational methods for extracting gene regulatory relationships from scRNA-seq and scATAC-seq data, the data...
7.
Karlsson K, Przybilla M, Kotler E, Khan A, Xu H, Karagyozova K, et al.
Nature
. 2023 May;
618(7964):383-393.
PMID: 37258665
The earliest events during human tumour initiation, although poorly characterized, may hold clues to malignancy detection and prevention. Here we model occult preneoplasia by biallelic inactivation of TP53, a common...
8.
Rockweiler N, Ramu A, Nagirnaja L, Wong W, Noordam M, Drubin C, et al.
Science
. 2023 Apr;
380(6641):eabn7113.
PMID: 37053313
Postzygotic mutations (PZMs) begin to accrue in the human genome immediately after fertilization, but how and when PZMs affect development and lifetime health remain unclear. To study the origins and...
9.
Wei Z, Hua K, Wei L, Ma S, Jiang R, Zhang X, et al.
Proc Natl Acad Sci U S A
. 2023 Apr;
120(15):e2216698120.
PMID: 37023129
Discovering DNA regulatory sequence motifs and their relative positions is vital to understanding the mechanisms of gene expression regulation. Although deep convolutional neural networks (CNNs) have achieved great success in...
10.
Lin Y, Wu T, Wan S, Yang J, Wong W, Wang Y
Nat Biotechnol
. 2022 Jan;
40(5):703-710.
PMID: 35058621
Single-cell multiomics data continues to grow at an unprecedented pace. Although several methods have demonstrated promising results in integrating several data modalities from the same tissue, the complexity and scale...