Steven A Kliewer
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Explore the profile of Steven A Kliewer including associated specialties, affiliations and a list of published articles.
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104
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12162
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Recent Articles
1.
Huffman K, Li L, Carstens R, Park H, Girard L, Avila K, et al.
Front Oncol
. 2023 Apr;
13:1025443.
PMID: 37035141
The glucocorticoid receptor (GR) is an important anti-cancer target in lymphoid cancers but has been understudied in solid tumors like lung cancer, although glucocorticoids are often given with chemotherapy regimens...
2.
Choi M, Schneeberger M, Fan W, Bugde A, Gautron L, Vale K, et al.
Cell Metab
. 2023 Mar;
35(3):429-437.e5.
PMID: 36889282
Animals that consume fermenting fruit and nectar are at risk of exposure to ethanol and the detrimental effects of inebriation. In this report, we show that the hormone FGF21, which...
3.
Lok J, Kliewer S, Mangelsdorf D
Mol Biochem Parasitol
. 2022 Jun;
250:111490.
PMID: 35697206
Mechanisms governing morphogenesis and development of infectious third-stage larvae (L3i) of parasitic nematodes have been likened to those regulating dauer development in Caenorhabditis elegans. Dauer regulatory signal transduction comprises initial...
4.
Romero A, Cobb S, Collins J, Kliewer S, Mangelsdorf D, Collins 3rd J
PLoS Pathog
. 2021 Dec;
17(12):e1010140.
PMID: 34910770
Schistosomes infect over 200 million of the world's poorest people, but unfortunately treatment relies on a single drug. Nuclear hormone receptors are ligand-activated transcription factors that regulate diverse processes in...
5.
Wang Z, Cheong M, Tsien J, Deng H, Qin T, Stoltzfus J, et al.
Elife
. 2021 Dec;
10.
PMID: 34874004
A prevalent feature of is a life-long and potentially lethal infection that is due to the nematode parasite's ability to autoinfect and, thereby, self-replicate within its host. Here, we investigated...
6.
Abu-Odeh M, Zhang Y, Reilly S, Ebadat N, Keinan O, Valentine J, et al.
Cell Rep
. 2021 Jun;
35(13):109331.
PMID: 34192547
The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion...
7.
Cheong M, Wang Z, Jaleta T, Li X, Lok J, Kliewer S, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(8).
PMID: 33602820
DAF-12 is nematode-specific nuclear receptor that has been proposed to govern development of the infectious stage of parasitic species, including Here, we identified a parasite-specific coactivator, called DAF-12 interacting protein-1...
8.
Omueti Ayoade K, Carranza F, Cho W, Wang Z, Kliewer S, Mangelsdorf D, et al.
Parasit Vectors
. 2020 Apr;
13(1):162.
PMID: 32238181
Background: While immune responses to the murine hookworm Nippostrongylus brasiliensis have been investigated, signaling pathways regulating development of infectious larvae (iL3) are not well understood. We hypothesized that N. brasiliensis...
9.
Hernandez G, Luo T, Javed T, Wen L, Kalwat M, Vale K, et al.
Sci Transl Med
. 2020 Jan;
12(525).
PMID: 31915301
The exocrine pancreas expresses the highest concentrations of fibroblast growth factor 21 (FGF21) in the body, where it maintains acinar cell proteostasis. Here, we showed in both mice and humans...
10.
Sun S, Kelekar S, Kliewer S, Mangelsdorf D
Genes Dev
. 2019 Jul;
33(15-16):1083-1094.
PMID: 31296559
The orphan nuclear receptor SHP (small heterodimer partner) is a well-known transcriptional corepressor of bile acid and lipid metabolism in the liver; however, its function in other tissues is poorly...