Steve P Gygi
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Explore the profile of Steve P Gygi including associated specialties, affiliations and a list of published articles.
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21
Citations
1342
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Recent Articles
11.
Zhou S, Appleman V, Rose C, Jun H, Yang J, Zhou Y, et al.
Life Sci Alliance
. 2018 Nov;
1(3):e201800029.
PMID: 30456354
Activation of the platelet-derived growth factor receptors (PDGFRs) gives rise to some of the most important signaling pathways that regulate mammalian cellular growth, survival, proliferation, and differentiation and their misregulation...
12.
Jun H, Appleman V, Wu H, Rose C, Pineda J, Yeo A, et al.
Nat Commun
. 2018 Aug;
9(1):3116.
PMID: 30082792
Glioblastoma multiforme (GBM) is an aggressive primary brain cancer that includes focal amplification of PDGFRα and for which there are no effective therapies. Herein, we report the development of a...
13.
Soustek M, Balsa E, Barrow J, Jedrychowski M, Vogel R, Smeitink J, et al.
Cell Death Dis
. 2018 Jun;
9(6):658.
PMID: 29855477
Mitochondrial mutations cause bioenergetic defects associated with failures to use the electron transfer chain and oxidize substrates. These defects are exacerbated under energetic stress conditions and ultimately cause cell deterioration...
14.
Mohideen F, Paulo J, Ordureau A, Gygi S, Harper J
Mol Cell Proteomics
. 2017 May;
16(7):1200-1216.
PMID: 28539327
TNFα is a potent inducer of inflammation due to its ability to promote gene expression, in part via the NFκB pathway. Moreover, in some contexts, TNFα promotes Caspase-dependent apoptosis or...
15.
Sharabi K, Lin H, Tavares C, Dominy J, Camporez J, Perry R, et al.
Cell
. 2017 Mar;
169(1):148-160.e15.
PMID: 28340340
Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for ...
16.
Barrow J, Balsa E, Verdeguer F, Tavares C, Soustek M, Hollingsworth 4th L, et al.
Mol Cell
. 2016 Sep;
64(1):163-175.
PMID: 27666594
Mitochondrial diseases comprise a heterogeneous group of genetically inherited disorders that cause failures in energetic and metabolic function. Boosting residual oxidative phosphorylation (OXPHOS) activity can partially correct these failures. Herein,...
17.
Zeng X, Jedrychowski M, Chen Y, Serag S, Lavery G, Gygi S, et al.
Genes Dev
. 2016 Aug;
30(16):1822-36.
PMID: 27566776
Brown adipocytes display phenotypic plasticity, as they can switch between the active states of fatty acid oxidation and energy dissipation versus a more dormant state. Cold exposure or β-adrenergic stimulation...
18.
Chouchani E, Kazak L, Jedrychowski M, Lu G, Erickson B, Szpyt J, et al.
Nature
. 2016 Jun;
536(7616):360.
PMID: 27281219
No abstract available.
19.
Chouchani E, Kazak L, Jedrychowski M, Lu G, Erickson B, Szpyt J, et al.
Nature
. 2016 Mar;
532(7597):112-6.
PMID: 27027295
Brown and beige adipose tissues can dissipate chemical energy as heat through thermogenic respiration, which requires uncoupling protein 1 (UCP1). Thermogenesis from these adipocytes can combat obesity and diabetes, encouraging...
20.
Kazak L, Chouchani E, Jedrychowski M, Erickson B, Shinoda K, Cohen P, et al.
Cell
. 2015 Oct;
163(3):643-55.
PMID: 26496606
Thermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their thermogenic activities can combat obesity and diabetes. Herein the functional adaptations to cold of brown and beige...