Edward T Chouchani
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Explore the profile of Edward T Chouchani including associated specialties, affiliations and a list of published articles.
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77
Citations
6485
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Recent Articles
1.
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST
Sprenger H, Mittenbuhler M, Sun Y, Van Vranken J, Schindler S, Jayaraj A, et al.
Cell Metab
. 2025 Feb;
PMID: 39965563
Ergothioneine (EGT) is a diet-derived, atypical amino acid that accumulates to high levels in human tissues. Reduced EGT levels have been linked to age-related disorders, including neurodegenerative and cardiovascular diseases,...
2.
Chang R, Toyoda H, Hobbs S, Richmond-Buccola D, Wein T, Burger N, et al.
bioRxiv
. 2025 Jan;
PMID: 39803557
Cyclic oligonucleotide-based antiviral signaling systems (CBASS) are bacterial anti-phage defense operons that use nucleotide signals to control immune activation. Here we biochemically screen 57 diverse and phages for the ability...
3.
Burger N, Mittenbuhler M, Xiao H, Shin S, Wei S, Henze E, et al.
Cell
. 2025 Jan;
188(3):832-850.e27.
PMID: 39742810
Zinc is an essential micronutrient that regulates a wide range of physiological processes, most often through zinc binding to protein cysteine residues. Despite being critical for modulation of protein function,...
4.
Katz J, Geng Y, Billingham L, Sadagopan N, DeLay S, Subbiah J, et al.
Sci Rep
. 2024 Sep;
14(1):21959.
PMID: 39304717
Glioblastoma is a Grade 4 primary brain tumor defined by therapy resistance, diffuse infiltration, and near-uniform lethality. The underlying mechanisms are unknown, and no treatment has been curative. Using a...
5.
Barnett D, Zimmer T, Booraem C, Palaguachi F, Meadows S, Xiao H, et al.
bioRxiv
. 2024 Sep;
PMID: 39229090
Neurodegenerative disorders alter mitochondrial functions, including the production of reactive oxygen species (ROS). Mitochondrial complex III (CIII) generates ROS implicated in redox signaling, but its triggers, targets, and disease relevance...
6.
Vargas-Castillo A, Sun Y, Smythers A, Grauvogel L, Dumesic P, Emont M, et al.
Cell Metab
. 2024 Jul;
36(9):2146-2155.e5.
PMID: 39084217
Although uncoupling protein 1 (UCP1) is established as a major contributor to adipose thermogenesis, recent data have illustrated an important role for alternative pathways, particularly the futile creatine cycle (FCC)....
7.
Sprenger H, Mittenbuhler M, Sun Y, Van Vranken J, Schindler S, Jayaraj A, et al.
bioRxiv
. 2024 Apr;
PMID: 38645260
Ergothioneine (EGT) is a diet-derived, atypical amino acid that accumulates to high levels in human tissues. Reduced EGT levels have been linked to age-related disorders, including neurodegenerative and cardiovascular diseases,...
8.
Burger N, Chouchani E
Curr Opin Chem Biol
. 2024 Feb;
79:102435.
PMID: 38382148
Cysteines are amenable to a diverse set of modifications that exhibit critical regulatory functions over the proteome and thereby control a wide range of cellular processes. Proteomic technologies have emerged...
9.
Reddy A, Winther S, Tran N, Xiao H, Jakob J, Garrity R, et al.
Nat Metab
. 2024 Feb;
6(3):567-577.
PMID: 38378996
Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole-body energy expenditure, counteracts obesity and antagonizes systemic tissue inflammation in mice. The plasma membrane transporters that...
10.
Burger N, Mittenbuhler M, Xiao H, Shin S, Bozi L, Wei S, et al.
bioRxiv
. 2024 Jan;
PMID: 38260676
Zinc is an essential micronutrient that regulates a wide range of physiological processes, principally through Zn binding to protein cysteine residues. Despite being critical for modulation of protein function, for...