Mark Jedrychowski
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Explore the profile of Mark Jedrychowski including associated specialties, affiliations and a list of published articles.
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22
Citations
1941
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Recent Articles
1.
Liang J, Vitale T, Zhang X, Jackson T, Yu D, Jedrychowski M, et al.
Nat Cancer
. 2025 Jan;
6(2):323-337.
PMID: 39824999
Cancer cells frequently rewire their metabolism to support proliferation and evade immune surveillance, but little is known about metabolic targets that could increase immune surveillance. Here we show a specific...
2.
Latorre-Muro P, Vitale T, Ravichandran M, Zhang K, Palozzi J, Bennett C, et al.
Nat Cell Biol
. 2025 Jan;
27(1):130-140.
PMID: 39753947
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles, including the endoplasmic reticulum. This communication is important in thermogenic adipocytes to increase the energy expenditure that controls...
3.
Liang J, Vitale T, Zhang X, Jackson T, Yu D, Jedrychowski M, et al.
bioRxiv
. 2023 Oct;
PMID: 37873273
Targeting of specific metabolic pathways in tumor cells has the potential to sensitize them to immune-mediated attack. Here we provide evidence for a specific means of mitochondrial respiratory Complex I...
4.
Sohn J, Mutlu B, Latorre-Muro P, Liang J, Bennett C, Sharabi K, et al.
Cell Metab
. 2023 Jul;
35(8):1356-1372.e5.
PMID: 37473754
Liver mitochondria undergo architectural remodeling that maintains energy homeostasis in response to feeding and fasting. However, the specific components and molecular mechanisms driving these changes and their impact on energy...
5.
Yin Z, Herron S, Silveira S, Kleemann K, Gauthier C, Mallah D, et al.
Nat Neurosci
. 2023 Jun;
26(7):1196-1207.
PMID: 37291336
Microglia play a critical role in brain homeostasis and disease progression. In neurodegenerative conditions, microglia acquire the neurodegenerative phenotype (MGnD), whose function is poorly understood. MicroRNA-155 (miR-155), enriched in immune...
6.
Liang J, Yu D, Luo C, Bennett C, Jedrychowski M, Gygi S, et al.
Nat Commun
. 2023 Jun;
14(1):3251.
PMID: 37277330
While targeted treatment against BRAF(V600E) improve survival for melanoma patients, many will see their cancer recur. Here we provide data indicating that epigenetic suppression of PGC1α defines an aggressive subset...
7.
Bennett C, OMalley K, Perry E, Balsa E, Latorre-Muro P, Riley C, et al.
Nat Chem Biol
. 2021 Mar;
17(6):703-710.
PMID: 33723432
The protein complexes of the mitochondrial electron transport chain exist in isolation and in higher order assemblies termed supercomplexes (SCs) or respirasomes (SC I+III+IV). The association of complexes I, III...
8.
Latorre-Muro P, OMalley K, Bennett C, Perry E, Balsa E, Tavares C, et al.
Cell Metab
. 2021 Feb;
33(3):598-614.e7.
PMID: 33592173
The architecture of cristae provides a spatial mitochondrial organization that contains functional respiratory complexes. Several protein components including OPA1 and MICOS complex subunits organize cristae structure, but upstream regulatory mechanisms...
9.
Yan S, Kumari M, Xiao H, Jacobs C, Kochumon S, Jedrychowski M, et al.
J Clin Invest
. 2021 Feb;
131(7).
PMID: 33571167
Adipose thermogenesis is repressed in obesity, reducing the homeostatic capacity to compensate for chronic overnutrition. Inflammation inhibits adipose thermogenesis, but little is known about how this occurs. Here we showed...
10.
Perry E, Bennett C, Luo C, Balsa E, Jedrychowski M, OMalley K, et al.
Nat Metab
. 2021 Jan;
3(1):33-42.
PMID: 33462515
Mitochondrial diseases (MDs) are a heterogeneous group of disorders resulting from mutations in nuclear or mitochondrial DNA genes encoding mitochondrial proteins. MDs cause pathologies with severe tissue damage and ultimately...