Stephen L Mathias
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Explore the profile of Stephen L Mathias including associated specialties, affiliations and a list of published articles.
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13
Citations
601
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Recent Articles
1.
Metzger V, Cannon D, Yang J, Mathias S, Bologa C, Waller A, et al.
PeerJ
. 2024 Jul;
12:e17470.
PMID: 38948230
TIN-X (Target Importance and Novelty eXplorer) is an interactive visualization tool for illuminating associations between diseases and potential drug targets and is publicly available at newdrugtargets.org. TIN-X uses natural language...
2.
Kelleher K, Sheils T, Mathias S, Yang J, Metzger V, Siramshetty V, et al.
Nucleic Acids Res
. 2023 Jan;
51(D1):D1405-D1416.
PMID: 36624666
The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of disease biology by perturbing them...
3.
Yang J, Grissa D, Lambert C, Bologa C, Mathias S, Waller A, et al.
Bioinformatics
. 2021 Jun;
37(21):3865-3873.
PMID: 34086846
Motivation: Genome-wide association studies can reveal important genotype-phenotype associations; however, data quality and interpretability issues must be addressed. For drug discovery scientists seeking to prioritize targets based on the available...
4.
Sheils T, Mathias S, Kelleher K, Siramshetty V, Nguyen D, Bologa C, et al.
Nucleic Acids Res
. 2020 Nov;
49(D1):D1334-D1346.
PMID: 33156327
In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be...
5.
Sheils T, Mathias S, Siramshetty V, Bocci G, Bologa C, Yang J, et al.
Curr Protoc Bioinformatics
. 2020 Jan;
69(1):e92.
PMID: 31898878
Pharos is an integrated web-based informatics platform for the analysis of data aggregated by the Illuminating the Druggable Genome (IDG) Knowledge Management Center, an NIH Common Fund initiative. The current...
6.
Ursu O, Holmes J, Bologa C, Yang J, Mathias S, Stathias V, et al.
Nucleic Acids Res
. 2018 Oct;
47(D1):D963-D970.
PMID: 30371892
DrugCentral is a drug information resource (http://drugcentral.org) open to the public since 2016 and previously described in the 2017 Nucleic Acids Research Database issue. Since the 2016 release, 103 new...
7.
Oprea T, Bologa C, Brunak S, Campbell A, Gan G, Gaulton A, et al.
Nat Rev Drug Discov
. 2018 Feb;
17(5):317-332.
PMID: 29472638
A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps...
8.
Lin Y, Mehta S, Kucuk-McGinty H, Turner J, Vidovic D, Forlin M, et al.
J Biomed Semantics
. 2017 Nov;
8(1):50.
PMID: 29122012
Background: One of the most successful approaches to develop new small molecule therapeutics has been to start from a validated druggable protein target. However, only a small subset of potentially...
9.
Nelson S, Oprea T, Ursu O, Bologa C, Zaveri A, Holmes J, et al.
J Am Med Inform Assoc
. 2017 Oct;
24(6):1169-1172.
PMID: 29016968
Therapeutic intent, the reason behind the choice of a therapy and the context in which a given approach should be used, is an important aspect of medical practice. There are...
10.
Cannon D, Yang J, Mathias S, Ursu O, Mani S, Waller A, et al.
Bioinformatics
. 2017 Apr;
33(16):2601-2603.
PMID: 28398460
Motivation: The increasing amount of peer-reviewed manuscripts requires the development of specific mining tools to facilitate the visual exploration of evidence linking diseases and proteins. Results: We developed TIN-X, the...