Jayme Holmes
Overview
Explore the profile of Jayme Holmes including associated specialties, affiliations and a list of published articles.
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14
Citations
752
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Recent Articles
1.
Vidovic D, Waller A, Holmes J, Sklar L, Schurer S
Drug Discov Today
. 2024 Mar;
29(5):103953.
PMID: 38508231
The Illuminating the Druggable Genome (IDG) consortium generated reagents, biological model systems, data, informatic databases, and computational tools. The Resource Dissemination and Outreach Center (RDOC) played a central administrative role,...
2.
Oprea T, Bologa C, Holmes J, Mathias S, Metzger V, Waller A, et al.
Drug Discov Today
. 2024 Jan;
29(3):103882.
PMID: 38218214
The Knowledge Management Center (KMC) for the Illuminating the Druggable Genome (IDG) project aims to aggregate, update, and articulate protein-centric data knowledge for the entire human proteome, with emphasis on...
3.
Kelleher K, Sheils T, Mathias S, Yang J, Metzger V, Siramshetty V, et al.
Nucleic Acids Res
. 2023 Jan;
51(D1):D1405-D1416.
PMID: 36624666
The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of disease biology by perturbing them...
4.
Avram S, Wilson T, Curpan R, Halip L, Borota A, Bora A, et al.
Nucleic Acids Res
. 2022 Dec;
51(D1):D1276-D1287.
PMID: 36484092
DrugCentral monitors new drug approvals and standardizes drug information. The current update contains 285 drugs (131 for human use). New additions include: (i) the integration of veterinary drugs (154 for...
5.
Kropiwnicki E, Binder J, Yang J, Holmes J, Lachmann A, Clarke D, et al.
Curr Protoc
. 2022 Jan;
2(1):e355.
PMID: 35085427
The Illuminating the Druggable Genome (IDG) consortium is a National Institutes of Health (NIH) Common Fund program designed to enhance our knowledge of under-studied proteins, more specifically, proteins unannotated within...
6.
Govinda K, Bocci G, Verma S, Hassan M, Holmes J, Yang J, et al.
ChemRxiv
. 2020 Nov;
PMID: 33200119
Strategies for drug discovery and repositioning are an urgent need with respect to COVID-19. We developed "REDIAL-2020", a suite of machine learning models for estimating small molecule activity from molecular...
7.
Sheils T, Mathias S, Kelleher K, Siramshetty V, Nguyen D, Bologa C, et al.
Nucleic Acids Res
. 2020 Nov;
49(D1):D1334-D1346.
PMID: 33156327
In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be...
8.
Avram S, Bologa C, Holmes J, Bocci G, Wilson T, Nguyen D, et al.
Nucleic Acids Res
. 2020 Nov;
49(D1):D1160-D1169.
PMID: 33151287
DrugCentral is a public resource (http://drugcentral.org) that serves the scientific community by providing up-to-date drug information, as described in previous papers. The current release includes 109 newly approved (October 2018...
9.
Ursu O, Holmes J, Bologa C, Yang J, Mathias S, Stathias V, et al.
Nucleic Acids Res
. 2018 Oct;
47(D1):D963-D970.
PMID: 30371892
DrugCentral is a drug information resource (http://drugcentral.org) open to the public since 2016 and previously described in the 2017 Nucleic Acids Research Database issue. Since the 2016 release, 103 new...
10.
Oprea T, Bologa C, Brunak S, Campbell A, Gan G, Gaulton A, et al.
Nat Rev Drug Discov
. 2018 Mar;
17(5):377.
PMID: 29567993
This corrects the article DOI: 10.1038/nrd.2018.14.