Pharos 2023: an Integrated Resource for the Understudied Human Proteome

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2023 Jan 10

PMID 36624666

Authors

Keith J Kelleher

Timothy K Sheils

Stephen L Mathias

Jeremy J Yang

Vincent T Metzger

Vishal B Siramshetty

Dac-Trung Nguyen

Lars Juhl Jensen

Dusica Vidovic

Stephan C Schurer

Jayme Holmes

Karlie R Sharma

Ajay Pillai

Cristian G Bologa

Jeremy S Edwards

Ewy A Mathe

Tudor I Oprea

Affiliations

Soon will be listed here.

Abstract

The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of disease biology by perturbing them with small molecules, biologics, or other therapeutic modalities. Two main products from the IDG effort are the Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/), which curates and aggregates information, and Pharos (https://pharos.nih.gov/), a web interface for fusers to extract and visualize data from TCRD. Since the 2021 release, TCRD/Pharos has focused on developing visualization and analysis tools that help reveal higher-level patterns in the underlying data. The current iterations of TCRD and Pharos enable users to perform enrichment calculations based on subsets of targets, diseases, or ligands and to create interactive heat maps and UpSet charts of many types of annotations. Using several examples, we show how to address disease biology and drug discovery questions through enrichment calculations and UpSet charts.

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