Stephen J Newhouse
Overview
Explore the profile of Stephen J Newhouse including associated specialties, affiliations and a list of published articles.
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36
Citations
3050
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Recent Articles
1.
Lee H, Metz A, McDiarmid A, Palmos A, Lee S, Curtis C, et al.
Brain Behav Immun Health
. 2021 Aug;
15:100286.
PMID: 34345870
Cell culture models are valuable tools to study biological mechanisms underlying health and disease in a controlled environment. Although their genotype influences their phenotype, subtle genetic variations in cell lines...
2.
Gotkine M, de Majo M, Wong C, Topp S, Michaelson-Cohen R, Epsztejn-Litman S, et al.
Neurobiol Aging
. 2021 Jul;
106:351.e1-351.e6.
PMID: 34272080
Loss of function (LoF) mutations in Optineurin can cause recessive amyotrophic lateral sclerosis (ALS) with some heterozygous LoF mutations associated with dominant ALS. The molecular mechanisms underlying the variable inheritance...
3.
Iacoangeli A, Lin T, Al Khleifat A, Jones A, Opie-Martin S, Coleman J, et al.
Cell Rep
. 2020 Oct;
33(4):108323.
PMID: 33113361
We meta-analyze amyotrophic lateral sclerosis (ALS) genome-wide association study (GWAS) data of European and Chinese populations (84,694 individuals). We find an additional significant association between rs58854276 spanning ACSL5-ZDHHC6 with ALS...
4.
Roubroeks J, Smith A, Smith R, Pishva E, Ibrahim Z, Sattlecker M, et al.
Neurobiol Aging
. 2020 Aug;
95:26-45.
PMID: 32745807
A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have...
5.
Patel H, Iniesta R, Stahl D, Dobson R, Newhouse S
J Alzheimers Dis
. 2020 Feb;
74(2):545-561.
PMID: 32065794
Background: The typical approach to identify blood-derived gene expression signatures as a biomarker for Alzheimer's disease (AD) have relied on training classification models using AD and healthy controls only. This...
6.
Iacoangeli A, Al Khleifat A, Jones A, Sproviero W, Shatunov A, Opie-Martin S, et al.
Acta Neuropathol Commun
. 2019 Jul;
7(1):115.
PMID: 31315673
The expansion of a hexanucleotide repeat GGGGCC in C9orf72 is the most common known cause of ALS accounting for ~ 40% familial cases and ~ 7% sporadic cases in the...
7.
Leirer D, Iyegbe C, Di Forti M, Patel H, Carra E, Fraietta S, et al.
Schizophr Res
. 2019 May;
209:88-97.
PMID: 31113746
Background: Psychosis is a condition influenced by an interaction of environmental and genetic factors. Gene expression studies can capture these interactions; however, studies are usually performed in patients who are...
8.
Patel H, Hodges A, Curtis C, Lee S, Troakes C, Dobson R, et al.
Brain Behav Immun
. 2019 May;
80:644-656.
PMID: 31063847
Individuals with intact cognition and neuropathology consistent with Alzheimer's disease (AD) are referred to as asymptomatic AD (AsymAD). These individuals are highly likely to develop AD, yet transcriptomic changes in...
9.
Patel H, Dobson R, Newhouse S
J Alzheimers Dis
. 2019 Mar;
68(4):1635-1656.
PMID: 30909231
Background: Microarray technologies have identified imbalances in the expression of specific genes and biological pathways in Alzheimer's disease (AD) brains. However, there is a lack of reproducibility across individual AD...
10.
Iacoangeli A, Al Khleifat A, Sproviero W, Shatunov A, Jones A, Opie-Martin S, et al.
Amyotroph Lateral Scler Frontotemporal Degener
. 2019 Mar;
20(3-4):207-215.
PMID: 30835568
Amyotrophic lateral sclerosis (ALS, MND) is a neurodegenerative disease of upper and lower motor neurons resulting in death from neuromuscular respiratory failure, typically within two years of first symptoms. Genetic...