Mark J Caulfield
Overview
Explore the profile of Mark J Caulfield including associated specialties, affiliations and a list of published articles.
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163
Citations
24361
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Recent Articles
1.
Magavern E, Marengo G, Sivathasan C, Mezzanzanica M, Wright A, Keen J, et al.
QJM
. 2025 Feb;
PMID: 39971322
Background: Variation in DNA is known to contribute to medication response, impacting both medicine effectiveness and incidence of adverse drug reactions (ADRs). However, clinical implementation of pharmacogenomics (PGx) has been...
2.
Magavern E, Deshmukh H, Asselin G, Theusch E, Trompet S, Li X, et al.
Pharmacol Res
. 2025 Jan;
212:107575.
PMID: 39798939
Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker....
3.
Leong I, Cabrera C, Cipriani V, Ross P, Turner R, Stuckey A, et al.
J Clin Oncol
. 2024 Oct;
43(6):682-693.
PMID: 39481076
Purpose: As part of the 100,000 Genomes Project, we set out to assess the potential viability and clinical impact of reporting genetic variants associated with drug-induced toxicity for patients with...
4.
Hepburn D, Hitchings A, Wilson K, Bollington L, Magavern E, Caulfield M, et al.
Br J Clin Pharmacol
. 2024 Oct;
91(1):246.
PMID: 39444163
No abstract available.
5.
Ibanez K, Jadhav B, Zanovello M, Gagliardi D, Clarkson C, Facchini S, et al.
Nat Med
. 2024 Oct;
30(11):3357-3368.
PMID: 39354197
Repeat expansion disorders (REDs) are a devastating group of predominantly neurological diseases. Together they are common, affecting 1 in 3,000 people worldwide with population-specific differences. However, prevalence estimates of REDs...
6.
Willems S, Ng N, Fernandez J, Fine R, Wheeler E, Wessel J, et al.
Wellcome Open Res
. 2024 Sep;
8():483.
PMID: 39280063
Background: Genome-wide association studies for glycemic traits have identified hundreds of loci associated with these biomarkers of glucose homeostasis. Despite this success, the challenge remains to link variant associations to...
7.
Magavern E, McDermott J, Caulfield M, Newman W
Eur Heart J Cardiovasc Pharmacother
. 2024 Aug;
10(6):481-483.
PMID: 39175266
No abstract available.
8.
Keaton J, Kamali Z, Xie T, Vaez A, Williams A, Goleva S, et al.
Nat Genet
. 2024 Apr;
56(5):778-791.
PMID: 38689001
Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10) from the largest...
9.
Magavern E, Kapil V, Saxena M, Gupta A, Caulfield M
Arterioscler Thromb Vasc Biol
. 2024 Feb;
44(4):784-793.
PMID: 38385287
Hypertension is a prevalent public health problem, contributing to >10 million deaths annually. Though multiple therapeutics exist, many patients suffer from treatment-resistant hypertension or try several medications before achieving blood...
10.
Collier D, Taylor M, Godec T, Shiel J, James R, Chowdury Y, et al.
J Am Heart Assoc
. 2024 Feb;
13(4):e030749.
PMID: 38323513
Background: The objective of the PERSONAL-CovidBP (Personalised Electronic Record Supported Optimisation When Alone for Patients With Hypertension: Pilot Study for Remote Medical Management of Hypertension During the COVID-19 Pandemic) trial...