Stephen H Prior
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Explore the profile of Stephen H Prior including associated specialties, affiliations and a list of published articles.
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17
Citations
327
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Recent Articles
1.
Singh W, Brown N, McCue H, Marriott S, Wilson R, Perry J, et al.
Chem Sci
. 2024 Mar;
15(13):4969-4980.
PMID: 38550701
The selective α,β-desaturation of cyclic carbonyl compounds, which are found in the core of many steroid and bioactive molecules, using green chemistry is highly desirable. To achieve this task, we...
2.
Parmar A, Lakshminarayanan R, Iyer A, Goh E, To T, Hoong Yam J, et al.
Eur J Med Chem
. 2023 Oct;
261:115853.
PMID: 37857144
Teixobactin is a cyclic undecadepsipeptide that has shown excellent potency against multidrug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). In this article, we present the design,...
3.
Parmar A, Iyer A, Prior S, Lloyd D, Goh E, Vincent C, et al.
Chem Sci
. 2018 Mar;
8(12):8183-8192.
PMID: 29568465
Teixobactin is a highly promising antibacterial depsipeptide consisting of four d-amino acids and a rare l--enduracididine amino acid. l--Enduracididine is reported to be important for the highly potent antibacterial activity...
4.
Parmar A, Lakshminarayanan R, Iyer A, Mayandi V, Goh E, Lloyd D, et al.
J Med Chem
. 2018 Jan;
61(5):2009-2017.
PMID: 29363971
The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only molecule in its...
5.
Parmar A, Iyer A, Lloyd D, Vincent C, Prior S, Madder A, et al.
Chem Commun (Camb)
. 2017 Jun;
53(55):7788-7791.
PMID: 28650495
The recently discovered cyclic depsipeptide, teixobactin, is a highly potent antibiotic against multi-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and Mycobaterium tuberculosis. It comprises of 4 D amino...
6.
Fulcher Y, Prior S, Masuko S, Li L, Pu D, Zhang F, et al.
Structure
. 2017 Jun;
25(7):1100-1110.e5.
PMID: 28648610
Heparan sulfate proteoglycans activate the matrix metalloproteinase-7 zymogen (proMMP-7) and recruit it in order to shed proteins from cell surfaces. This occurs in uterine and mammary epithelia, bacterial killing, lung...
7.
Parmar A, Prior S, Iyer A, Vincent C, Lysebetten D, Breukink E, et al.
Chem Commun (Camb)
. 2017 Jan;
53(12):2016-2019.
PMID: 28124045
The discovery of the highly potent antibiotic teixobactin, which kills the bacteria without any detectable resistance, has stimulated interest in its structure-activity relationship. However, a molecular structure-activity relationship has not...
8.
Parmar A, Iyer A, Vincent C, Lysebetten D, Prior S, Madder A, et al.
Chem Commun (Camb)
. 2016 Mar;
52(36):6060-3.
PMID: 26984316
The discovery of the new antibiotic teixobactin has been timely in the race for unearthing novel antibiotics wherein the emergence of drug resistant bacteria poses a serious threat worldwide. Herein,...
9.
Prior S, Byrne T, Tokmina-Roszyk D, Fields G, Van Doren S
J Biol Chem
. 2016 Feb;
291(15):7888-901.
PMID: 26887942
Collagenolysis is essential in extracellular matrix homeostasis, but its structural basis has long been shrouded in mystery. We have developed a novel docking strategy guided by paramagnetic NMR that positions...
10.
Prior S, Fulcher Y, Koppisetti R, Jurkevich A, Van Doren S
Structure
. 2015 Oct;
23(11):2099-110.
PMID: 26439767
Matrix metalloproteinase-7 (MMP-7) sheds signaling proteins from cell surfaces to activate bacterial killing, wound healing, and tumorigenesis. The mechanism targeting soluble MMP-7 to membranes has been investigated. Nuclear magnetic resonance...