Steven R Van Doren
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Explore the profile of Steven R Van Doren including associated specialties, affiliations and a list of published articles.
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54
Citations
754
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Recent Articles
1.
Shammi U, Luan Z, Xu J, Hamid A, Flors L, Cassani J, et al.
Res Diagn Interv Imaging
. 2024 Dec;
8:100035.
PMID: 39678163
Rationale And Objectives: To support cardiac MR acquisitions during breathing without ECG, we developed software to mitigate the effects of respiratory displacement of the heart. The algorithm resolves respiratory motions...
2.
Van Doren S, Scott B, Koppisetti R
Structure
. 2023 Aug;
31(10):1184-1199.e3.
PMID: 37625399
The fusion peptide of SARS-CoV-2 spike is essential for infection. How this charged and hydrophobic domain occupies and affects membranes needs clarification. Its depth in zwitterionic, bilayered micelles at pH...
3.
Gruber K, Ji R, Gallazzi F, Jiang S, Van Doren S, Tao Y, et al.
ACS Pharmacol Transl Sci
. 2022 May;
5(5):344-361.
PMID: 35592439
During the development of a melanocortin (MC) peptide drug to treat the condition of cachexia (a hypermetabolic state producing lean body mass wasting), we were confronted with the need for...
4.
Van Doren S
Biochem Soc Trans
. 2022 Mar;
50(2):839-851.
PMID: 35343563
Pancreatic cancer incurs the worst survival rate of the major cancers. High levels of the protease matrix metalloproteinase-7 (MMP-7) in circulation correlate with poor prognosis and limited survival of patients....
5.
Koppisetti R, Fulcher Y, Van Doren S
J Am Chem Soc
. 2021 Aug;
143(33):13205-13211.
PMID: 34375093
The receptor binding and proteolysis of Spike of SARS-CoV-2 release its S subunit to rearrange and catalyze viral-cell fusion. This deploys the fusion peptide for insertion into the cell membranes...
6.
Ye Y, Nikovics K, To A, Lepiniec L, Fedosejevs E, Van Doren S, et al.
Nat Commun
. 2020 Dec;
11(1):6191.
PMID: 33273474
In plants, light-dependent activation of de novo fatty acid synthesis (FAS) is partially mediated by acetyl-CoA carboxylase (ACCase), the first committed step for this pathway. However, it is not fully...
7.
Ye Y, Fulcher Y, Sliman D, Day M, Schroeder M, Koppisetti R, et al.
J Biol Chem
. 2020 May;
295(29):9901-9916.
PMID: 32467229
Acetyl-CoA carboxylase (ACCase) catalyzes the first committed step in the synthesis of fatty acids. The multisubunit ACCase in the chloroplast is activated by a shift to pH 8 upon light...
8.
Namanja A, Xu J, Wu H, Sun Q, Upadhyay A, Sun C, et al.
J Biomol NMR
. 2019 Sep;
73(12):675-685.
PMID: 31541395
Protein-based NMR spectroscopy has proven to be a very robust method for finding fragment leads to protein targets. However, one limitation of protein-based NMR is that the data acquisition and...
9.
Stiers K, Xu J, Lee Y, Addison Z, Van Doren S, Beamer L
ACS Omega
. 2019 Aug;
2(11):8445-8452.
PMID: 31457382
Phosphoglucosamine mutase (PNGM) is an evolutionarily conserved bacterial enzyme in the peptidoglycan biosynthetic pathway, catalyzing the reversible conversion between glucosamine 1- and 6-phosphate. Previous structural studies of PNGM from the...
10.
Marcink T, Simoncic J, An B, Knapinska A, Fulcher Y, Akkaladevi N, et al.
Structure
. 2018 Nov;
27(2):281-292.e6.
PMID: 30471921
Critical to migration of tumor cells and endothelial cells is the proteolytic attack of membrane type 1 matrix metalloproteinase (MT1-MMP) upon collagen, growth factors, and receptors at cell surfaces. Lipid...