Abhishek Iyer
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Explore the profile of Abhishek Iyer including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
135
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Recent Articles
1.
Author Correction: Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap
Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, et al.
Nat Biotechnol
. 2025 Mar;
PMID: 40044831
No abstract available.
2.
Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, et al.
Nat Biotechnol
. 2024 Oct;
PMID: 39375448
Unlike sequencing-based methods, which require cell lysis, optical pooled genetic screens enable investigation of spatial phenotypes, including cell morphology, protein subcellular localization, cell-cell interactions and tissue organization, in response to...
3.
Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, et al.
bioRxiv
. 2024 Jan;
PMID: 38234835
Pooled genetic screens are powerful tools to study gene function in a high-throughput manner. Typically, sequencing-based screens require cell lysis, which limits the examination of critical phenotypes such as cell...
4.
Parmar A, Lakshminarayanan R, Iyer A, Goh E, To T, Hoong Yam J, et al.
Eur J Med Chem
. 2023 Oct;
261:115853.
PMID: 37857144
Teixobactin is a cyclic undecadepsipeptide that has shown excellent potency against multidrug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). In this article, we present the design,...
5.
De Geyter E, Antonatou E, Kalaitzakis D, Smolen S, Iyer A, Tack L, et al.
Chem Sci
. 2021 Jun;
12(14):5246-5252.
PMID: 34163760
Recent dramatic expansion in potential uses of protein conjugates has fueled the development of a wide range of protein modification methods; however, the desirable single-site multi-functionalization of proteins has remained...
6.
Iyer A, Madder A, Singh I
Future Microbiol
. 2019 Apr;
14:457-460.
PMID: 31033354
No abstract available.
7.
Malkawi R, Iyer A, Parmar A, Lloyd D, Goh E, Taylor E, et al.
Pharmaceutics
. 2018 Oct;
10(4).
PMID: 30314324
Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant (MRSA) without detectable resistance. In this work, we describe the...
8.
Gunnoo S, Iyer A, Vannecke W, Decoene K, Hebbrecht T, Gettemans J, et al.
Chem Commun (Camb)
. 2018 Oct;
54(84):11929-11932.
PMID: 30285017
Methodologies to conjugate proteins to property-enhancing entities are highly sought after. We report a remarkably simple strategy for conjugating proteins bearing accessible cysteines to unprotected peptides containing a Cys(Scm) protecting...
9.
Parmar A, Iyer A, Prior S, Lloyd D, Goh E, Vincent C, et al.
Chem Sci
. 2018 Mar;
8(12):8183-8192.
PMID: 29568465
Teixobactin is a highly promising antibacterial depsipeptide consisting of four d-amino acids and a rare l--enduracididine amino acid. l--Enduracididine is reported to be important for the highly potent antibacterial activity...
10.
Parmar A, Lakshminarayanan R, Iyer A, Mayandi V, Goh E, Lloyd D, et al.
J Med Chem
. 2018 Jan;
61(5):2009-2017.
PMID: 29363971
The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only molecule in its...