Stephen E Girardin
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Explore the profile of Stephen E Girardin including associated specialties, affiliations and a list of published articles.
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174
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Recent Articles
21.
Maisonneuve C, Tsang D, Foerster E, Robert L, Mukherjee T, Prescott D, et al.
Cell Rep
. 2021 Jan;
34(4):108677.
PMID: 33503439
Pioneering studies from the early 1980s suggested that bacterial peptidoglycan-derived muramyl peptides (MPs) could exert either stimulatory or immunosuppressive functions depending, in part, on chronicity of exposure. However, this Janus-faced...
22.
Bracey N, Platnich J, Lau A, Chung H, Hyndman M, MacDonald J, et al.
Life Sci Alliance
. 2020 Dec;
4(3).
PMID: 33376129
The pryin domain (PYD) domain is involved in protein interactions that lead to assembly of immune-sensing complexes such as inflammasomes. The repertoire of PYD-containing genes expressed by a cell type...
23.
NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart
Zhang H, Xiao Y, Nederlof R, Bakker D, Zhang P, Girardin S, et al.
Front Immunol
. 2020 Dec;
11:591815.
PMID: 33362773
Background: NOD-like receptors (NLR) are intracellular sensors of the innate immune system, with the NLRP3 being a pro-inflammatory member that modulates cardiac ischemia-reperfusion injury (IRI) and metabolism. No information is...
24.
Goyal S, Tsang D, Maisonneuve C, Girardin S
Microbes Infect
. 2020 Nov;
23(6-7):104774.
PMID: 33189870
The intestine is inhabited by a diverse range of microorganisms, which requires the host to employ numerous barrier measures to prevent bacterial invasion. However, the intestinal microbiota additionally acts symbiotically...
25.
Mukherjee T, Ramaglia V, Abdel-Nour M, Bianchi A, Tsalikis J, Chau H, et al.
J Biol Chem
. 2020 Nov;
296:100050.
PMID: 33168630
Large cytosolic protein aggregates are removed by two main cellular processes, autophagy and the ubiquitin-proteasome system, and defective clearance of these protein aggregates results in proteotoxicity and cell death. Recently,...
26.
Killackey S, Philpott D, Girardin S
J Cell Biol
. 2020 Sep;
219(11).
PMID: 32926082
Mitophagy is an evolutionarily conserved process involving the autophagic targeting and clearance of mitochondria destined for removal. Recent insights into the complex nature of the overlapping pathways regulating mitophagy illustrate...
27.
Girardin S, Cuziol C, Philpott D, Arnoult D
FEBS J
. 2020 Sep;
288(10):3094-3107.
PMID: 32892501
The integrated stress response (ISR) is an evolutionary conserved stress response pathway that leads to a global arrest in translation as well as to the expression of specific genes, such...
28.
Winsor N, Killackey S, Philpott D, Girardin S
Biotechniques
. 2020 Aug;
69(4):249-256.
PMID: 32806949
Mitophagy is the process by which mitochondria are selectively targeted and removed via autophagic machinery to maintain mitochondrial homeostasis in the cell. Recently, flow cytometry-based assays that utilize the fluorescent...
29.
Prescott D, Maisonneuve C, Yadav J, Rubino S, Girardin S, Philpott D
Proc Natl Acad Sci U S A
. 2020 May;
117(20):10946-10957.
PMID: 32350141
Four decades ago, it was identified that muramyl dipeptide (MDP), a peptidoglycan-derived bacterial cell wall component, could display immunosuppressive functions in animals through mechanisms that remain unexplored. We sought to...
30.
Lavagna A, Auger J, Girardin S, Gisch N, Segura M, Gottschalk M
Pathogens
. 2020 Feb;
9(2).
PMID: 32098284
serotype 2 is an important porcine bacterial pathogen and zoonotic agent causing sudden death, septic shock and meningitis. These pathologies are the consequence of an exacerbated inflammatory response composed of...