Stephen E Girardin
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Explore the profile of Stephen E Girardin including associated specialties, affiliations and a list of published articles.
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174
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16278
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Recent Articles
11.
Killackey S, Bi Y, Philpott D, Arnoult D, Girardin S
Autophagy
. 2022 Sep;
19(5):1601-1603.
PMID: 36170592
Mitochondria rely on efficient protein import across their membranes for optimal function. We have shown that numerous mitochondrial stressors all converge on a common pathway disrupting this import efficiency. We...
12.
Boroumand P, Prescott D, Mukherjee T, Bilan P, Wong M, Shen J, et al.
Elife
. 2022 Sep;
11.
PMID: 36125130
During obesity and high fat-diet (HFD) feeding in mice, sustained low-grade inflammation includes not only increased pro-inflammatory macrophages in the expanding adipose tissue, but also bone marrow (BM) production of...
13.
Cabral-Fernandes L, Goyal S, Farahvash A, Tsalikis J, Philpott D, Girardin S
Mol Cell Biol
. 2022 Aug;
42(9):e0024122.
PMID: 36005752
Upon pathogen infection, intricate innate signaling cascades are induced to initiate the transcription of immune effectors, including cytokines and chemokines. Transcription factor EB (TFEB), a master regulator of lysosomal biogenesis...
14.
Tsang D, Wang R, De Sa O, Ayyaz A, Foerster E, Bayer G, et al.
Gut Microbes
. 2022 Aug;
14(1):2108281.
PMID: 35939622
The small intestinal epithelial barrier inputs signals from the gut microbiota in order to balance physiological inflammation and tolerance, and to promote homeostasis. Understanding the dynamic relationship between microbes and...
15.
Killackey S, Bi Y, Soares F, Hammi I, Winsor N, Abdul-Sater A, et al.
Mol Cell
. 2022 Jun;
82(15):2815-2831.e5.
PMID: 35752171
Protein import into mitochondria is a highly regulated process, yet how cells clear mitochondria undergoing dysfunctional protein import remains poorly characterized. Here we showed that mitochondrial protein import stress (MPIS)...
16.
Chiaranunt P, Burrows K, Ngai L, Cao E, Liang H, Tai S, et al.
J Immunol
. 2022 Mar;
208(7):1782-1789.
PMID: 35256512
Commensal intestinal protozoa, unlike their pathogenic relatives, are neglected members of the mammalian microbiome. These microbes have a significant impact on the host's intestinal immune homeostasis, typically by elevating anti-microbial...
17.
Bruce J, Burns G, Soh W, Nair P, Sherwin S, Fan K, et al.
Brain Behav Immun
. 2022 Jan;
101:335-345.
PMID: 35093492
Functional dyspepsia (FD) affects up to 15% of the population and is characterised by recurring upper gastrointestinal (GI) symptoms occurring in the absence of clinically identifiable pathology. Psychological stress is...
18.
Nathan N, Philpott D, Girardin S
Microbes Infect
. 2021 Jun;
23(6-7):104849.
PMID: 34146716
Our understanding of the composition and the function of the intestinal microbiota has significantly increased over the past few years. In a series of reviews focusing on the role of...
19.
Foerster E, Mukherjee T, Cabral-Fernandes L, Rocha J, Girardin S, Philpott D
Autophagy
. 2021 Apr;
18(1):86-103.
PMID: 33906557
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-mediated recycling of organelles and protein aggregates, as well as the destruction of intracellular pathogens. Its role in the maintenance of...
20.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...